Brian Feldman MD, PhD, Assistant Professor, Department of Pediatrics, Endocrinology and Diabetes Division, Stanford University School of Medicine
Research Description: Dr. Feldman is a physician-scientist with a PhD in molecular biology and subspecialty medical training in Pediatric Endocrinology; the combination of these two areas of expertise provide unique insights and approaches to study the endocrine system. His academic clinical practice includes caring for patients with both type 1 (T1D) and type-2 diabetes (T2D) at Stanford’s Packard Children’s Hospital and Clinics. A major focus of his research laboratory is aimed at elucidating the pathophysiology of T1D and T2D and to develop novel approaches to diagnose and treat these diseases. In this regard, he has focused on two steroid hormones: glucocorticoids and vitamin D signaling via the glucocorticoid receptor (GR) and vitamin D receptor (VDR) respectively. His laboratory uses these hormonal signals as medically relevant molecular probes to reveal context-specific functions in adipose biology and the influence of these effects on both local and systemic metabolism. His studies on glucocorticoids have identified circadian clock components as being embedded in GR signaling pathways that regulate adipogenesis. His studies on VDR, elucidated an interesting adipose tissue-specific mechanism for regulating fatty acid composition that may promote the brown fat activity. Currently his group is testing whether modulating this VDR pathway can protect against diet-induced obesity and the development of diabetes. In addition, his group’s interest in diabetes led to creation of a state-of-the-art platform that enables high-resolution and multiplexed monitoring of circulating biomarkers, including autoantibodies, in patients with or at-risk for the development of type 1 diabetes.
Selected relevant publications (Stanford DRC Members in BOLD):
1. Wong JC, Krueger KC, Costa MJ, Aggarwal A, Du H, McLaughlin TL, Feldman BJ. “A Glucocorticoid and Diet-responsive Pathway Toggles Adipocyte Precursor Cell Activity In Vivo” Science Signaling, 9, 2016.
2. Ji L, Gupta M, Feldman BJ. “Vitamin D Regulates Fatty Acid Composition in Subcutaneous Adipose Tissue Through Elovl3” Endocrinology 157: 91-97, 2016.
3. Chao CS, McKnight KD, Cox KL, Chang AL, Kim SK, Feldman BJ. “Novel GATA6 Mutations in Patients with Pancreatic Agenesis and Congenital Heart Malformations” PLoS ONE, 10: e0118449, 2015.
4. Zhang B, Kumar RB, Dai H, Feldman BJ. “A Plasmonic Chip for Biomarker Discovery and Diagnosis of Type-1 Diabetes” Nature Medicine 20: 948-953, 2014.
5. Malloy PJ, Feldman BJ. “Cell Autonomous Regulation of Brown Fat Identity Gene UCP1 by Unliganded Vitamin D Receptor” Molecular Endocrinology (10):1632-1642, 2013.
6. Costa M, So AY, Kassik K, Krueger KC, Pillsbury ML, Fu Y, Ptacek LJ, Yamamoto KR, Feldman BJ. “Circadian Rhythm Gene Per3 is an Inhibitor of the Adipocyte Fate” Journal of Biological Chemistry 286: 9063- 9070, 2011.
7. So AY. Bernal TU, Pillsbury ML, Yamamoto KR, Feldman BJ. “Glucocorticoid Regulation of the Circadian Clock Modulates Glucose Homeostasis” Proceedings of the National Academy of Sciences 106: 17482-17587, 2009.