Geoffrey C. Gurtner, MD, Johnson & Johnson Distinguished Professor of Surgery; Vice Chairman for
Research, Department of Surgery, Stanford University School of Medicine
Research Description: Dr. Gurtner’s laboratory focuses on elucidating the mechanisms underlying tissue repair, an important aspect of diabetes complications. His laboratory seeks to develop strategies for treating impaired regenerative states in diabetes, which has required them to develop single cell analytics to overcome cellular heterogeneity and identify unique cells in complex organisms. This approach includes the ability to characterize cells based on innate function, isolation of cells with precision based on unique surface marker expression and enrichment or depletion of target cells for the treatment of disease. His work has led to the identification of critical defects in the wound microenvironment and progenitor cell function that contribute to impaired healing in diabetes. Specifically, his group has identified that stabilization and transactivation of the master hypoxia regulator HIF1a enhances healing in diabetes.
Selected relevant publications (Stanford DRC Members in BOLD):
- Rennert RC, Januszyk M, Sorkin M, Rodrigues M, Maan Z, Duscher D, Whittam A, Ching MT, Paik K, Kosaraju R, Findlay M, Glotzbach JP, Butte AJ, Gurtner GC. Rational Identification of Novel Surface Marker Profiles to Enhance Cell Based Therapies. Nature Communications 7:11945, 2016.
- Paik KJ, Maan ZN, Zielins ER, Duscher D, Whittam AJ, Morrison SD, Brett EA, Ransom RC, Hu MS, Wu JC, Gurtner GC, Longaker MT, Wan DC. Short Hairpin RNA Silencing of PHD-2 Improves Neovascularization and Functional Outcomes in Diabetic Wounds and Ischemic Limbs. PLoS One. 11(3):e0150927, 2016.
- Januszyk M, Sorkin M, Glotzbach J, Vial I, Maan Z, Rennert R, Duscher D, Thangarajah H, Longaker M, Butte A, Gurtner GC. Diabetes Irreversibly Depletes Bone Marrow-Derived Mesenchymal Progenitor Cell Subpopulations. Diabetes 63(9):3047-56, 2014.
- Duscher D, Neosfartu E, Wong VW, Maan Z, Rennert RC, Inayathullah M, Januszyk M, Rodrigues M, Malkovskiy A, Whitmore AJ, Walmsley G, Galvez M, Whittam AJ, Brownlee M, Rajadas J, Gurtner GC. Transdermal Deferoxamine Prevents Pressure-Induced Diabetic Ulcers. Proceedings of the National Academy of Sciences. 112(1):94-9, 2015.
- Januszyk M and Gurtner GC. High-Throughput Single Cell Analysis for Wound Healing Applications. Advances in Wound Care 2(9):457-469, 2013.