Greg Charville, MD PhD, Assistant Professor of Pathology, Stanford University School of Medicine
Research Description: Dr. Charville diagnoses and studies gastrointestinal and hepatopancreatobiliary diseases with a particular focus on mechanisms of inititaiton and progression of human pancreatic tumors. He has worked with several collaborative groups to develop new techniques for histologic evaluation of human tissues and discovered features of human tumors that help to predict their clinical behavior. His work has focused on the interplay of developmental signaling mechanisms and tumor suppressor pathways to derive insight into the cellular origins of human neoplasia, the mechanisms of tumor cell initiation and propagation, and the effect of the tumor microenvironment on tumor growth and therapeutic intervention.
Dr. Charville has collaborations and interactions with other members of the PCRG, including Drs. Kim and Longacre.
Selected relevant publications (Stanford DRC Members in BOLD):
Charville, G.W.*, Longacre, T.A. (2017) Surgical Pathology of Gastrointestinal Stromal Tumors: Practical Implications of Morphologic and Molecular Heterogeneity for Precision Medicine. Adv. Anat. Pathol. 24, 336-353. (PMID 28820749)
Hsueh, B., Burns, V., Pauerstein, P., Holzem, K., Ye, L., Engberg, K., Wang, A-C., Gu, X., Chakravarthy, H., Arda, E., Charville, G.W., Vogel, H., Efimov, I.R., Kim, S.K., Deisseroth, K. (2017) Pathways to clinical CLARITY: volumetric analysis of irregular, soft, and heterogeneous tissues in development and disease. Sci. Rep. 7, 5899). PMCID: PMC5517617