James Priest, MD, Assistant Professor of Pediatrics (Cardiology), Stanford University School of Medicine
Research Description: Congenital heart disease (CHD) affects 1% of all live births, and with survival rates approaching 99% is increasing in prevalence. Survivors of CHD require lifelong care for cardiac morbidities and are at elevated risk for a variety of non-cardiac disease. Maternal diabetes of all types has long been recognized as a risk factor for CHD in offspring. In population-based studies, the risk for disease in offspring appears to correlate with glucose control (Oyen 2016), and Dr. Priest’s studies of second and first trimester maternal blood samples suggest the risk for CHD is correlated with glucose levels even in women without a diagnosis of diabetes (Priest 2015, Helle 2017). However, the relationship of maternal glucose metabolism to normal and abnormal cardiac development is uncharacterized, and the mechanism by which risk is conferred from mother to fetus is unknown. Dr. Priest’s diabetes related research interest is in the mechanism by which diabetes in early pregnancy confers risk for congenital heart disease in offspring.
Selected relevant publications (Stanford DRC Members in BOLD):
- Helle EI, Biegley P, Knowles JW, Leader JB, Pendergrass S, Yang W, Reaven GR, Shaw GM, Ritchie M, Priest JR: First trimester plasma glucose values in women without diabetes are associated with risk for congenital heart disease in offspring. J Pediatr 2018; 195: 275-8.
- Priest JR, Yang W, Reaven G, Knowles JW, Shaw GM: Maternal midpregnancy glucose levels and risk of congenital heart disease in offspring. JAMA Pediatr 2015; 169: 1112-6