Mary N. Teruel, PhD, Assistant Professor, Department of Chemical and Systems Biology, Stanford University School of Medicine
Research Description: Dr. Teruel and her research group have been studying adipogenesis and adipocyte function for over 15 years, beginning with developing a very sensitive total-internal reflection microscopy approach to for the first time measure glucose transporter translocation and PI3K signaling simultaneously in single adipocyte cells, and with a particular emphasis on understanding PIP3-signaling that regulates insulin action and glucose uptake capability in normal and diabetic setting. Dr. Teruel’s group developed the first quantitative molecular model of adipogenesis and identified the protein network architecture that controls adipogenesis (references 1-2 below). Her lab has also developed novel targeted proteomics approaches to identify mechanisms regulating insulin resistance in mouse models (references 3-4 below) and in human patients. Her group has long-standing, productive collaborations with multiple members of the SDRC, detailed below and in the proposal. Dr. Teruel recently received a Stanford DRC P&F award for 2017 and anticipates this will catalyze additional interactions with SDRC investigators.
Selected relevant publications (Stanford DRC members in BOLD):
1. Ahrends R, Ota A, Kovary KM, Kudo T, Park BO, Teruel MN. (2014). Controlling low rates of cell differentiation through noise and ultra-high feedback. Science. Jun 20; 344:1384-9. PMID: 24948735. Awarded an Editors’ Choice rating by the Science magazine signaling editors.
2. Park BO, Ahrends R, Teruel MN. (2012). Consecutive positive feedback loops create a bistable switch that controls preadipocyte to adipocyte conversion. Cell Reports. Oct 25; 2(4): 976-90. Epub 2012 Oct. 11. PMID: 23063366.
3. Ota A, Kovary KM, Wu OH, Ahrends R, Costa MJ, Shen W, Feldman BJ, Kraemer FB, Teruel MN. (2015). Using SRM mass spectrometry to profile nuclear protein abundance differences between adipose tissue depots of insulin resistant mice. Journal of Lipid Research. May; 56(5):1068-78. Epub Apr 3. PMID: 25840986.
4. Khor VK, Ahrends R, Shen W, Cortez Y, Teruel MN, Salman A, and Kraemer FB. (2014). The proteome of cholesteryl-ester-enriched versus triacylglycerol-enriched lipid droplets. Plos One. Aug 11; 9(8):e105047. PMID: 25111084.