Samuel Strober, MD, Professor, Department of Medicine, Division of Rheumotology and Immunology, Stanford University School of Medicine
Research Description: Dr. Strober is a senior investigator and world expert in immune tolerance. In addition to the detailed study of murine models to understand transplantation tolerance, Dr. Strober has successfully translated the use of combined solid organ transplantation and bone marrow transplantation to induce immune tolerance to solid organ allografts, especially kidney. In the past year, Dr. Strober has established new collaborations to develop combined islet transplantation with bone marrow transplantation to induce tolerance. His laboratory has also begun to compare the antigen presenting cell profile of patients tolerant of their kidney graft to the antigen presenting cell profile from subjects in other groups including normal healthy controls and patients newly diagnosed with Type 1 diabetes, in collaboration with Drs. E. Meyer and S. Kim. In addition, Dr. Strober is actively involved with advising on development of islet auto- and allo-transplant programs at Stanford, in collaborations with Drs. Meyer, S.K. Kim, Thakor, Park, Habtezion, Visser and DiGiusto.
Selected relevant publications (Stanford DRC Members in BOLD):
1. Scandling, J.D., Busque, S., Shizuru, J.A., Engleman, E.G., Strober, S. Induced immune tolerance for kidney transplantation. New Engl. J. Med 365(14):1359-60 2011
2. Scandling, J. D., Busque, S., Dejbakhsh-Jones, S., Benike, C., Sarwal, M., Millan, M.T., Shizuru, J., Lowsky, R., Engleman, E.G., and Strober, S. Tolerance and withdrawal of immunosuppressive drugs in patients given kidney and hematopoietic cell transplants. AJT12 (5):1133-1145 2012
3. Scandling JD, Busque S, Shizuru JA, Lowsky R, Hoppe R, Dejbakhsh-Jones S, Jensen K, Shori A, Strober JA, Lavori P, Turnbull BB Engleman EG, Strober S. Chimerism, graft survival, and withdrawal of immunosupressive drugs in HLA matched and mismatched patients after kidney and hematopoietic cell transplantation. AJT. 15: 695-704. 2015.