Agnieszka Czechowicz, MD, PhD, Assistant Professor of Pediatrics, Stanford University School of Medicine
Research Description: Dr. Czechowicz’s research is primarily aimed at understanding how hematopoietic stem cells interact with their microenvironment in order to subsequently modulate these interactions to ultimately improve bone marrow transplantation. In particular she has been focused on antibody-based conditioning regimens that enable safe and effective transplantation; and have developed several pre-clinical methods that are rapidly developing into clinical therapies. In animal models her lab have found that antibodies can be used to induce donor tolerance, even across large MHC-mismatches. This may aid tremendously in using bone marrow transplantation to induce mixed chimerism in patients and ultimately aid in tolerance to solid organ transplants; including pancreatic transplants that could subsequently be used to treat diabetes. In addition, through safe bone marrow transplantation it is possible to eliminate auto-reactive host immune systems and replace them with donor immune systems further preventing Type I diabetes in susceptible or pre-diabetic individuals.
Selected relevant publications (Stanford DRC Members in BOLD):
- Czechowicz A, Kraft D, Weissman IL, Bhattacharya D: Efficient transplantation via antibody-based clearance of hematopoietic stem cell niches. Science 2007; 318: 1296-9.
- Palchaudhuri R, Saez B, Hoggatt J, Schajnovitz A, Sykes DB, Tate TA, Czechowicz A, Kfoury Y, Ruchika FN, Rossi DJ, Verdine GL, Mansour MK, Scadden DT: Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin. Nat Biotechnol 2016; 34: 738-45.