Aijaz Ahmed, MD, Professor of Medicine (Gastroenterology and Hepatology), Stanford University School of Medicine
Research Description: Obesity-related nonalcoholic fatty liver disease (NAFLD)/ nonalcoholic steatohepatitis (NASH) is the hepatic manifestation of metabolic syndrome – insulin resistance. NAFLD is the most common liver disease in the United States (US). NASH (the progressive subset of NAFLD) is the second leading cause of liver disease among adults awaiting liver transplantation in the US (Gastroenterology, 2015). NASH is also the most rapidly growing indication for liver transplantation in patients with hepatocellular carcinoma in the US (Hepatology, 2014). Complications of NASH-related end-stage liver disease and its post-transplant outcomes have been the focus of my clinical research.
Despite the rise in NAFLD-related end-stage liver disease and liver transplantation in the US, cardiovascular disease remains the leading cause of mortality in patients with NASH. Therefore, I hope to establish inter-departmental collaboration essential in improving our understanding of NAFLD and shift the focus on primary prevention. Dr. Ahmed collaborates with experts in insulin resistance, like Joshua Knowles with a focus on genetic counseling/testing. Together, they hope to improve the clinical and translational research efforts focusing on the role of insulin resistance in patients with NAFLD.
Selected relevant publications (Stanford DRC Members in BOLD):
- Wu Y, Ahmed A, Kamal A. Donor diabetes mellitus is an independent risk factor for graft loss in HCV positive but not HCV negative liver transplant recipients. Dig Dis Sci 2013; 58:574-8.
- Wong RJ, Cheung R, Perumpail RB, Holt EW, Ahmed A. Diabetes mellitus, and not obesity, is associated with lower survival following liver transplantation. Dig Dis Sci 2015; 60(4):1036-44.
- Stepanova M, Clement S, Wong R, Saab S, Ahmed A, Younossi ZM. Patients with Diabetes and Chronic Liver Disease Are at Increased Risk for Overall Mortality: A Population Study from the United States. Clin Diabetes 2017; 35(2):79-83.