Andrew Hoffman

Andrew R. Hoffman, MD, Professor, Department of Medicine, Division of Endocrinology, Metabolism and Gerontology, Stanford University School of Medicine

 

Research Description: Dr. Hoffman’s research focuses on examining epigenetic mechanisms of gene expression and on studying the role of insulin-like growth factors (IGF) and growth hormone in normal physiology, in metabolic derangements and in cancer development. His studies have implications for the therapeutic use of growth hormone and IGF in development and in the clinical consequences of aging. He is currently studying the natural history of bone health in elderly men and neuroendocrine function in aging and traumatic brain injury. Dr. Hoffman is the PI on the NIH T32 Endocrine Training Grant, now in its 41st consecutive year of funding.

 

Selected relevant publications (Stanford DRC Members in BOLD):

1.         Marquez JL, Rubinstein S, Fattor JA, Shah O, Hoffman AR and Friedlander AL.  Cyclic hypobaric hypoxia improves markers of glucose metabolism in middle-aged men. High Alt Med Biol 14:263-272, 2013.

2.         Napoli N, Strotmeyer ES, Ensrud KE, Sellmeyer DE, Bauer DC, Hoffman AR, Dam TT, Barrett-Connor E, Palermo L, Orwoll ES, Cummings SR, Black DM, and Schwartz AV. Fracture risk in diabetic elderly men: the MrOS study. Diabetologia 57: 2057-2065, 2014.

3.         Miljkovic I, Kuipers AL, Cauley JA, Prasad T, Lee CG, Ensrud KE, Cawthon PM, Hoffman AR, Dam TT, Gordon CL, and Zmuda JM; Osteoporotic Fractures in Men Study Group. Greater skeletal muscle fat infiltration is associated with higher all-cause and cardiovascular mortality in older men. J Gerontol A Biol Sci Med Sci 70: 1134-1140, 2015.

4.         Napoli N, Schafer AL, Lui LY, Cauley JA, Strotmeyer ES, Le Blanc ES, Hoffman AR, Lee CG, Black DM, and Schwartz AV. Serum 25-hydroxyvitamin D level and incident type 2 diabetes in older men, the Osteoporotic fractures in men study (MROS). Bone 90:181-184, 2016.