Avnesh S. Thakor, MD PhD, Assistant Professor, Department of Radiology, Stanford University School of Medicine
Research Description: Dr. Thakor’s research program is focused on (i) novel strategies to regenerate the pancreas and (ii) the developmental biology of the pancreas. In particular, he is developing new ways to deliver and home mesenchymal stem cells to the pancreas using locoregional strategies combined with imaging guidance. In addition, Dr. Thakor is assessing the development and programming of pancreatic islets, during normal and complicated pregnancies, especially with respect to the islet microcirculation. Understanding how the islet microcirculation develops prenatally in the fetus, and how it evolves and changes postnatally in the newborn child, will help in the understanding of why some children develop diabetes. Based on this information, he seeks to develop new molecular imaging techniques which can be clinically translated to identify high risk children and novel therapeutic interventions which could prevent or reverse deleterious programming of the pancreas before the clinical presentation of diabetes. Together with several members of the Stanford DRC and Islet Core, Dr. Thakor is also working to establish a human islet auto-transplant program at Stanford.
Selected relevant publications (Stanford DRC Members in BOLD):
Adipose tissue-derived mesenchymal stem cells rescue the function of islets transplanted in sub-therapeutic numbers via their angiogenic properties. Ren G, Rezaee M, Razavi M, Taysir A, Wang J, Thakor AS. Cell Tissue Res. 2019 Jun; 376(3): 353-364. PMID: 30707291
Percutaneous autologous pancreatic islet cell transplantation for traumatic pancreatic injury. Thakor AS, Sangha BS, Ho SG, Warnock GL, Meloche M, Liu DM. J Clin Endocrinol Metab. 2015 Apr;100(4):1230-3.
Divergence of mechanistic pathways mediating cardiovascular aging and developmental programming of cardiovascular disease. Allison BJ, Kaandorp JJ, Kane AD, Camm EJ, Lusby C, Cross CM, Nevin-Dolan R, Thakor AS, Derks JB, Tarry-Adkins JL, Ozanne SE, Giussani DA. FASEB J. 2016 May;30(5):1968-75.
Melatonin modulates the fetal cardiovascular defense response to acute hypoxia. Thakor AS, Allison BJ, Niu Y, Botting KJ, Serón-Ferré M, Herrera EA, Giussani DA. J Pineal Res. 2015 Aug;59(1):80-90.
Redox modulation of the fetal cardiovascular defence to hypoxaemia. Thakor AS, Richter HG, Kane AD, Dunster C, Kelly FJ, Poston L, Giussani DA. J Physiol. 2010 Nov 1;588(Pt 21):4235-47.
The relation of S100beta and metabolic and endocrine responses to acute fetal hypoxemia. Thakor AS, Gazzolo D, Frulio R, Giussani DA. Front Biosci (Elite Ed). 2010 Jan 1;2:59-67.