Bruce Buckingham, MD, Professor, Department of Pediatrics, Endocrinology and Diabetes Division, Stanford University School of Medicine
Research Description: Dr. Buckingham's research focuses on continuous glucose monitoring and the development of a closed-loop system (artificial pancreas). He was the PI at Stanford on the JDRF multicenter continuous glucose monitoring (CGM) study and for the DirecNet study group. He was PI on the first studies testing the Medtronic 670G hybrid closed-loop system. He has conducted studies with Ed Damiano and the Bionic Pancreas, and Dr Buckingham was the PI testing an insulin-only version of the Bionic Pancreas. In the next year he is working on several NIH multicenter collaborative studies testing in home closed-loop control with Roman Hovorka and the University of Virginia and TypeZero. He is also conducting studies for BigFoot, Tandem, Animas, Insulet, and RPI (Rensselaer) for development of closed loop systems. His team is also developing long term insulin infusion sets (IDE G150256). As part of DirecNet he is doing a long term longitudinal study of MRI and neurocognitive changes in children with diabetes, relating changes to their glycemic control measured by A1c and CGM, in collaboration with Stanford DRC members, Drs. Reiss, Hood Wilson, Maahs and Aye.
Selected relevant publications (Stanford DRC Members in BOLD):
1. Buckingham B, Cheng P, Beck RW, Kollman C, Ruedy KJ, et al. CGM-measured glucose values have a strong correlation with C-peptide, HbA1c and IDAAC, but do poorly in predicting C-peptide levels in the two years following onset of diabetes. Diabetologia. 2015; 58(6):1167-74.
2. Ly, T.T., Roy, A., Grosman, B., Shin, J., Campbell, A., Monirabbasi, S., Liang, B., von Eyben, R., Shanmugham, S., Clinton, P., Buckingham, B.A.Day and Night Closed-Loop Control Using the Integrated Medtronic Hybrid Closed-Loop System in Type 1 Diabetes at Diabetes Camp. Diabetes Care38: 1205-1211, 2015.
3. Bergenstal RM, Garg S, Weinzimer SA, Buckingham BA, Bode BW, Tamborlane WV, Kaufman FR. Safety of a Hybrid Closed-Loop Insulin Delivery System in Patients With Type 1 Diabetes. JAMA 316: 1407-1408, 2016.
Mauras, N., Mazaika, P., Buckingham, B., Weinzimer, S., White, N. H., Tsalikian, E., Hershey, T., Cato, A., Cheng, P., Kollman, C., Beck, R. W., Ruedy, K., Aye, T., Fox, L., Arbelaez, A. M., Wilson, D., Tansey, M., Tamborlane, W., Peng, D., Marzelli, M., Winer, K. K., Reiss, A.L. Longitudinal Assessment of Neuroanatomical and Cognitive Differences in Young Children With Type 1 Diabetes: Association With Hyperglycemia. Diabetes 64: 1770-1779, 2015.