Eric A. Appel, PhD, Assistant Professor of Materials Science & Engineering and (by courtesy) Bioengineering; Terman Faculty Fellow, Stanford University School of Engineering
Research description: The Appel lab at Stanford integrates concepts and approaches from supramolecular chemistry and natural/synthetic materials to tackle healthcare challenges of critical importance to society, including diabetes mellitus. They have developed a platform of materials with unique, tunable, and stimuli-responsive properties that they are exploiting as the basis for novel treatment strategies for a range of disease targets. Relevant to diabetes, Appel’s group has developed “smart” excipient technology affording unprecedented stabilization of monomeric insulin, a strategy that forms the basis of novel ultra-fast-acting insulin formulations for treatment of diabetes. They have several on-going collaborations with multiple members of the Stanford DRC that focus on the translation of their new material technologies.
Selected relevant publications (Stanford DRC Members in BOLD):
1. Appel, E.A., Tibbitt, M.W., Webber, M.J., Mattix, B.A., Veiseh, O., Langer, R. Self-Assembled Hydrogels Utilising Polymer-Nanoparticle Interactions. Nature Commun, 2015, 6, No. 6295. PMID: 25695516.
2. Yu, A.C., Chen, H., Chan, D., Agmon, G., Stapleton, L.M., Sevit, A.M., Tibbitt, M.W., Acosta, J.D., Zhang, T., Franzia, P.W., Langer, R., Appel, E.A. 2016. Scalable Manufacturing of Moldable Hydrogels for Industrial Applications. Proc. Nat. Acad. Sci. USA 113(50):14255-14260.
3. Webber, M.J.^, Appel, E.A.^, Vinciguerra, B., Thapa, L.S., Cortinas, A.B., Jhunjhunwala, S., Isaacs, L.*, Langer, R.*, Anderson, D.G.* 2016. Supramolecular PEGylation of Biopharmaceuticals. Proc. Nat. Acad. Sci. USA 113(50):14189-14194. ^ equal contribution.