Eric R. Gross, MD, PhD, Assistant Professor, Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine
Research Description: Dr. Gross’s laboratory focuses on mitochondrial function in the context of cardiovascular disease. They are studying the role for an ion channel, transient receptor potential vanilloid 1 (TRPV1) at the mitochondria in the cardiovascular system, with a focus on cardiac myocytes and endothelial cells. The study of TRPV1 in endothelial cells is a new direction for his lab which has tremendous potential to unlock the cellular mechanisms of endothelial cell dysfunction caused by diabetes mellitus and provide treatment strategies. In support of this work, he is the recipient of a P&F award jointly administered by the Stanford Cardiovascular Institute and the Stanford DRC.
Selected relevant publications (Stanford DRC Members in BOLD):
1. Cole SP, Gross ER. Happy 53rd birthday GIK: insulin, cake and presents. Anesthesiology 123 (2): 249-50, 2015.
2. Gross ER. Hsu AK. Gross GJ. Diabetes abolishes morphine-induced cardioprotection via multiple pathways of upstream of glycogen synthase kinase- 3β. Diabetes, 56(1):127-36, 2007.
3. Gross ER, LaDisa JF, Wienreich D, Kress TT, Olson LE, Hettrick DA, Pagel PS, Warltier DC, Kersten JR. Reactive oxygen species modulate coronary wall shear stress and endothelial function during hyperglycemia. American Journal of Physiology: Heart and Circulatory Physiology, 284(5): H1552-1559, 2003.
4. Pritchard KA, Ackerman AW, Gross ER, Stepp DW, Shi Y, Fontana JT, Baker JE, Sessa WC. Heat shock protein 90 mediates the balance of nitric oxide and superoxide anion from endothelial nitric-oxide synthase. Journal of Biological Chemistry, 276:17621-4, 2001.