Everett Meyer

Everett Meyer MD, PhD, Assistant Professor, Department of Medicine, Division of Blood and Marrow Transplantation, Stanford University School of Medicine

 

Research Description: Dr. Meyer has a focus on the study of human immune tolerance in the hematopoietic stem cell setting and islet cell transplantation. He studies murine pre-clinical models with a focus on T cell immunotherapy, T regulatory cell and invariant NKT cell biology and non-myeloblative hematopoietic stem cell transplantation for tolerance induction. In established collaborations with Dr. Seung Kim, Dr. Meyer has developed genetic engineering to reprogram Tregulatory cells to target them to mouse islet allografts and human islet xenografts. This approach has resulted in some startling discoveries: (1) genetically engineered Tregulatory cells producing Chimeric Antigen Receptor (CAR) are much better at preventing islet graft rejection than normal Tregulatory cells and (2) genetically engineered Tregulatory cells can alter the immune system to create new immune memory and tolerance. Dr. Meyer also has expertise in using high throughput sequencing and flow cytometry to monitor T cells responses in patients. He is principle investigator of two phase I or phase I/II clinical trials using T regulatory cells to prevent or treat graft-versus host disease. His laboratory has also begun to compare the antigen presenting cell profile of patients tolerant of their kidney graft to the antigen presenting cell profile from subjects in other groups including normal healthy controls and patients newly diagnosed with Type 1 diabetes, in collaboration with Drs. S. Strober and S. Kim. Together with several members of the Stanford DRC and Islet Core, Dr. Meyer is leading efforts to establish a human islet auto-transplant program at Stanford, which would be the only active program of its kind on the west coast. In January, 2017, Dr. Meyer received a coveted JDRF Career Development Award in recognition of his promise as a diabetes investigator. Dr. Meyer is co-leader of the Immunology and Transplantation in Diabetes Research Affinity Group of the SDRC. He is also co-directing the SDRC Diabetes Immune Monitoring Core, with Dr. Holden Maecker.

Selected relevant publications (Stanford DRC Members in BOLD):

1.         Meyer EH, Hsu AR, Liliental J, Löhr A, Florek M, Zehnder JL, Strober S, Lavori P, Miklos DB, Johnson DS, Negrin RS. A distinct evolution of the T-cell repertoire categorizes treatment refractory gastrointestinal acute graft-versus-host disease. Blood 121:4955-62, 2013.