Fahim Abbasi

 Fahim Abbasi, MD, Clinical Assistant Professor, Department of Cardiovascular Medicine, Stanford University School of Medicine

Research Description: Dr. Abbasi’s research over the past 20 years has focused on the role of insulin resistance in the pathophysiology of type 2 diabetes and cardiovascular disease. These research efforts have increased our understanding of how differences in insulin-mediated glucose disposal modulate risk of cardiovascular disease in persons with and without diabetes. Dr. Abbasi has expertise in ‘gold-standard’ methods for quantification of insulin-mediated glucose disposal and pancreatic beta cell function in humans, and he collaborates actively and productively with many members of SDRC.

Selected relevant publications (SDRC members in BOLD):

  1. D, Cholankeril G, Kim SH, Abbasi F, Knowles JW, Ahmed A. Increasing Mortality Among Patients With Diabetes and Chronic Liver Disease From 2007 to 2017. Clin Gastroenterol Hepatol. 2020 Apr;18(4):992-994. doi: 10.1016/j.cgh.2019.06.011. PMID: 31220638; PMCID: PMC7064319.

  2. Banda JM, Sarraju A, Abbasi F, Parizo J, Pariani M, Ison H, Briskin E, Wand H, Dubois S, Jung K, Myers SA, Rader DJ, Leader JB, Murray MF, Myers KD, Wilemon K, Shah NH, Knowles JW. Finding missed cases of familial hypercholesterolemia in health systems using machine learning. NPJ Digit Med. 2019 Apr 11;2:23. doi: 10.1038/s41746-019-0101-5. PMID: 31304370; PMCID: PMC6550268.

  3. Shahbazi M, Cundiff P, Zhou W, Lee P, Patel A, D'Souza SL, Abbasi F, Quertermous T, Knowles JW. The role of insulin as a key regulator of seeding, proliferation, and mRNA transcription of human pluripotent stem cells. Stem Cell Res Ther. 2019 Jul 29;10(1):228. doi: 10.1186/s13287-019-1319-5. PMID: 31358052; PMCID: PMC6664730.

  4. Abbasi F, Tern PJ, Reaven GM. Plasma glucose concentration 60 min post oral glucose load and risk of type 2 diabetes and cardiovascular disease: Pathophysiological implications. Diab Vasc Dis Res. 2019 Jul;16(4):337-343. doi: 10.1177/1479164119827239. PMID: 30755013.

  5. Kho PF, Wary N, Zanetti D, Abbasi F, Knowles JW, Panyard DJ, Watson KT; RISC Investigators; Stell L, Lazzeroni LC, Gustafsson S, Lind L, Petrie JR, Assimes TL. Cross-sectional, interventional, and causal investigation of insulin sensitivity using plasma proteomics in diverse populations. Metabolism. 2025 Aug;169:156263. doi: 10.1016/j.metabol.2025.156263. Epub 2025 Apr 11. PMID: 40221021; PMCID: PMC12170150. 

  6. Metwally AA, Perelman D, Park H, Wu Y, Jha A, Sharp S, Celli A, Ayhan E, Abbasi F, Gloyn AL, McLaughlin T, Snyder M. Predicting Type 2 Diabetes Metabolic Phenotypes Using Continuous Glucose Monitoring and a Machine Learning Framework. medRxiv [Preprint]. 2024 Sep 9:2024.07.20.24310737. doi: 10.1101/2024.07.20.24310737. PMID: 39108516; PMCID: PMC11302614. 

  7. Zhao L, Zhou J, Abbasi F, Fathzadeh M, Knowles JW, Leung LLK, Morser J. Chemerin in Participants with or without Insulin Resistance and Diabetes. Biomedicines. 2024 Apr 22;12(4):924. doi: 10.3390/biomedicines12040924. PMID: 38672278; PMCID: PMC11048116. 

  8. Zanetti D, Stell L, Gustafsson S, Abbasi F, Tsao PS, Knowles JW; RISC Investigators; Zethelius B, Ärnlöv J, Balkau B, Walker M, Lazzeroni LC, Lind L, Petrie JR, Assimes TL. Plasma proteomic signatures of a direct measure of insulin sensitivity in two population cohorts. Diabetologia. 2023 Sep;66(9):1643-1654. doi: 10.1007/s00125-023-05946-z. Epub 2023 Jun 17. PMID: 37329449; PMCID: PMC10390625. 

  9. Abbasi F, Lamendola C, Harris CS, Harris V, Tsai MS, Tripathi P, Abbas F, Reaven GM, Reaven PD, Snyder MP, Kim SH, Knowles JW. Statins Are Associated With Increased Insulin Resistance and Secretion. Arterioscler Thromb Vasc Biol. 2021 Nov;41(11):2786-2797. doi: 10.1161/ATVBAHA.121.316159. Epub 2021 Aug 26. PMID: 34433298; PMCID: PMC8551023. 

  10. Kim SH, Abbasi F, Nachmanoff C, Stefanakis K, Kumar A, Kalra B, Savjani G, Mantzoros CS. Effect of the glucagon-like peptide-1 analogue liraglutide versus placebo treatment on circulating proglucagon-derived peptides that mediate improvements in body weight, insulin secretion and action: A randomized controlled trial. Diabetes Obes Metab. 2021 Feb;23(2):489-498. doi: 10.1111/dom.14242. Epub 2020 Nov 19. PMID: 33140542; PMCID: PMC7856054. 

  11. Rowland CM, Abbasi F, Shiffman D, Knowles JW, McPhaul MJ. The relationship between insulin resistance and ion mobility lipoprotein fractions. Am J Prev Cardiol. 2022 Dec 25;13:100457. doi: 10.1016/j.ajpc.2022.100457. PMID: 36619297; PMCID: PMC9816659. 

  12. Frangou S, Abbasi F, Watson K, Haas SS, Antoniades M, Modabbernia A, Myoraku A, Robakis T, Rasgon N. Hippocampal volume reduction is associated with direct measure of insulin resistance in adults. Neurosci Res. 2022 Jan;174:19-24. doi: 10.1016/j.neures.2021.07.006. Epub 2021 Aug 2. PMID: 34352294. 

  13. Xiao S, Li VL, Lyu X, Chen X, Wei W, Abbasi F, Knowles JW, Tung AS, Deng S, Tiwari G, Shi X, Zheng S, Farrell L, Chen ZZ, Taylor KD, Guo X, Goodarzi MO, Wood AC, Chen YI, Lange LA, Rich SS, Rotter JI, Clish CB, Tahir UA, Gerszten RE, Benson MD, Long JZ. Lac-Phe mediates the effects of metformin on food intake and body weight. Nat Metab. 2024 Apr;6(4):659-669. doi: 10.1038/s42255-024-00999-9. Epub 2024 Mar 18. PMID: 38499766; PMCID: PMC11062621. 

  14. Zhang P, Munier JJ, Wiese CB, Vergnes L, Link JC, Abbasi F, Ronquillo E, Scheker K, Muñoz A, Kuang YL, Theusch E, Lu M, Sanchez G, Oni-Orisan A, Iribarren C, McPhaul MJ, Nomura DK, Knowles JW, Krauss RM, Medina MW, Reue K. X chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction. Nat Commun. 2024 Jul 2;15(1):5571. doi: 10.1038/s41467-024-49764-2. PMID: 38956041; PMCID: PMC11219728. 

  15. Metwally AA, Perelman D, Park H, Wu Y, Jha A, Sharp S, Celli A, Ayhan E, Abbasi F, Gloyn AL, McLaughlin T, Snyder MP. Prediction of metabolic subphenotypes of type 2 diabetes via continuous glucose monitoring and machine learning. Nat Biomed Eng. 2024 Dec 23:10.1038/s41551-024-01311-6. doi: 10.1038/s41551-024-01311-6. Epub ahead of print. PMID: 39715896; PMCID: PMC12183321. 

  16. Wu Y, Ehlert B, Metwally AA, Perelman D, Park H, Brooks AW, Abbasi F, Michael B, Celli A, Bejikian C, Ayhan E, Lu Y, Lancaster SM, Hornburg D, Ramirez L, Bogumil D, Pollock S, Wong F, Bradley D, Gutjahr G, Rangan ES, Wang T, McGuire L, Venkat Rangan P, Ræder H, Shipony Z, Lipson D, McLaughlin T, Snyder MP. Individual variations in glycemic responses to carbohydrates and underlying metabolic physiology. Nat Med. 2025 Jul;31(7):2232-2243. doi: 10.1038/s41591-025-03719-2. Epub 2025 Jun 4. PMID: 40467897; PMCID: PMC12283382.