Francois Haddad

Francois Haddad, MD, Clinical Professor, Department of Medicine, Division of Cardiovascular Medicine; Director, Biomarker and Phenotypic Core Laboratory, Stanford Cardiovascular Institute, Stanford University School of Medicine

Research Description: Dr. Haddad’s area of expertise is heart failure and cardiovascular imaging. He directs the Stanford Cardiovascular Institute Biomarker and Phenotypic Core Laboratory. His laboratory has a long history of collaboration with the Human Immune Monitoring Center, and SDRC members in the Department Genetics, the Pulmonary Division in the Dept. of Medicine and the Stem Cell Institute. As part of SDRC, Dr. Haddad’s team provides comprehensive cardiovascular, endothelial function and exercise physiology phenotypes of study participants. They have developed methods to characterize ventricular dysfunction in patients with insulin resistance or diabetes mellitus. Their efforts with SDRC investigators will help elucidate mechanisms underlying early stages of ventricular dysfunction, endothelial dysfunction or vascular aging in patients with insulin resistance or diabetes mellitus. His contributions to SDRC are essential for efforts focusing on diabetic cardiomyopathy, early vascular aging in patients with diabetes mellitus, autonomic dysfunction and drug response studies.

Selected relevant publications (Stanford DRC Members in BOLD):

  1. Nishi T, Kobayashi Y, Christle JW, Cauwenberghs N, Boralkar K, Moneghetti K, Amsallem M, Hedman K, Contrepois K, Myers J, Mahaffey KW, Schnittger I, Kuznetsova T, Palaniappan L, Haddad F. Incremental value of diastolic stress test in identifying subclinical heart failure in patients with diabetes mellitus. Eur Heart J Cardiovasc Imaging. 2020 Aug 1;21(8):876-884. PMID: 32386203; PMCID: PMC7369686. 

  2. Faroqi L, Bonde S, Goni DT, Wong CW, Wong M, Walai K, Araya S, Azamey S, Schreiner G, Bandy M, Raghuram SS, Mittal A, Mukherji A, Wangdak T, Talamoa R, Vera K, Nacif-Coelho C, Cde LG, Christensen M, Johannsen N, Haddad F, Moharir M, Palaniappan L. STRONG-D: Strength training regimen for normal weight diabetics: Rationale and design. Contemp Clin Trials. 2019 Mar;78:101-106. PMID: 30625372. 

  3. Contrepois K, Wu S, Moneghetti KJ, Hornburg D, Ahadi S, Tsai MS, Metwally AA, Wei E, Lee-McMullen B, Quijada JV, Chen S, Christle JW, Ellenberger M, Balliu B, Taylor S, Durrant MG, Knowles DA, Choudhry H, Ashland M, Bahmani A, Enslen B, Amsallem M, Kobayashi Y, Avina M, Perelman D, Schüssler-Fiorenza Rose SM, Zhou W, Ashley EA, Montgomery SB, Chaib H, Haddad F, Snyder MP. Molecular Choreography of Acute Exercise. Cell. 2020 May 28;181(5):1112-1130.e16. PMID: 32470399; PMCID: PMC7299174. 

  4. Harper RL, Zhou X, Marciano DP, Cao A, Wang L, Chen G, Adil MS, Zhou W, Maguire P, Deivanayagam S, Yu Q, Viswanathan V, Yang D, Martin M, Isobe S, Otsuki S, Burgess J, Inglis A, Kelley D, Del Rosario PA, Hsi A, Haddad F, Zamanian RT, Boehm M, Snyder MP, Rabinovitch M. Altered maturation and activation state of circulating monocytes is associated with their enhanced recruitment in pulmonary arterial hypertension. Respir Res. 2025 Apr 15;26(1):148. doi: 10.1186/s12931-025-03182-0. PMID: 40234964; PMCID: PMC11998417. 

  5. Taylor S, Isobe S, Cao A, Contrepois K, Benayoun BA, Jiang L, Wang L, Melemenidis S, Ozen MO, Otsuki S, Shinohara T, Sweatt AJ, Kaplan J, Moonen JR, Marciano DP, Gu M, Miyagawa K, Hayes B, Sierra RG, Kupitz CJ, Del Rosario PA, Hsi A, Thompson AAR, Ariza ME, Demirci U, Zamanian RT, Haddad F, Nicolls MR, Snyder MP, Rabinovitch M. Endogenous Retroviral Elements Generate Pathologic Neutrophils in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2022 Oct 15;206(8):1019-1034. doi: 10.1164/rccm.202102-0446OC. PMID: 35696338; PMCID: PMC9801997. 

  6. Sayed N, Huang Y, Nguyen K, Krejciova-Rajaniemi Z, Grawe AP, Gao T, Tibshirani R, Hastie T, Alpert A, Cui L, Kuznetsova T, Rosenberg-Hasson Y, Ostan R, Monti D, Lehallier B, Shen-Orr SS, Maecker HT, Dekker CL, Wyss-Coray T, Franceschi C, Jojic V, Haddad F, Montoya JG, Wu JC, Davis MM, Furman D. An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging. Nat Aging. 2021 Jul;1:598-615. doi: 10.1038/s43587-021-00082-y. Epub 2021 Jul 12. PMID: 34888528; PMCID: PMC8654267. 

  7. Kobayashi Y, Christle JW, Contrepois K, Nishi T, Moneghetti K, Cauwenberghs N, Myers J, Kuznetsova T, Palaniappan L, Haddad F. Peripheral Oxygen Extraction and Exercise Limitation in Asymptomatic Patients with Diabetes Mellitus. Am J Cardiol. 2021 Jun 15;149:132-139. PMID: 33757787. 

  8. Mukherji AB, Lu D, Qin F, Hedlin H, Johannsen NM, Chung S, Kobayashi Y, Haddad F, Lamendola C, Basina M, Talamoa R, Myers J, Palaniappan L. Effectiveness of a Community-Based Structured Physical Activity Program for Adults With Type 2 Diabetes: A Randomized Clinical Trial. JAMA Netw Open. 2022 Dec 1;5(12):e2247858. PMID: 36542382. 

  9. Kobayashi Y, Nishi T, Christle JW, Cauwenberghs N, Kuznetsova T, Palaniappan L, Haddad F. Epicardial fat and Stage B heart failure among overweight/obese and normal weight individuals with diabetes mellitus. Int J Cardiovasc Imaging. 2023 Dec;39(12):2451-2461. doi: 10.1007/s10554-023-02944-5. Epub 2023 Sep 11. PMID: 37695438; PMCID: PMC11088949.