Howard Y. Chang, MD, PhD, Professor, Department of Dermatology, Director NIH/NHGRI Center for Genomic Excellence, Stanford University School of Medicine
Research Description: Dr. Chang’s research has focused on mechanisms that coordinate the activities of large number of genes in cell fate control. He has made a series of seminal discoveries that introduced the important and pervasive roles of long noncoding RNAs in biological regulation. His group has substantial experience in epigenetics and RNA biology, including invention of new methods for epigenomic profiling, map RNA occupancy on chromatin, and define RNA structures genome-wide, Chang’s group pioneered methods to identify key regulators of large-scale transcriptional programs; these methods have been highly fruitful for studies of diabetes, cancer and aging by Stanford investigators, and rapidly adopted by the community of science focused on diabetes research or other research worldwide. Dr. Chang was previously an investigator on a UO1 of the NIH Beta-Cell Biology Consortium (BCBC). He is a tireless, cheerful collaborator of many investigators in the Stanford DRC. Dr. Chang also leads the NHGRI Center of Excellence in Genomic Science at Stanford.
Selected relevant publications (Stanford DRC Members in BOLD):
1. Arda HE, Li L, Tsai J, Torre EA, Rosli Y, Peiris H, Spitale RC, Dai C, Gu X, Qu K, Wang P, Wang J, Grompe M, Scharfmann R, Snyder MS, Bottino R, Powers AC, Chang HY, Kim SK. Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function. Cell Metab 23:909-20, 2016.
2. ATAC-see reveals the accessible genome by transposase-mediated imaging and sequencing. Chen X, Shen Y, Draper W, Buenrostro JD, Litzenburger U, Cho SW, Satpathy AT, Carter AC, Ghosh RP, East-Seletsky A, Doudna JA, Greenleaf WJ, Liphardt JT, Chang HY. Nat Methods doi: 10.1038/nmeth.4031, 2016.
3. Single-cell chromatin accessibility reveals principles of regulatory variation. Buenrostro JD, Wu B, Litzenburger UM, Ruff D, Gonzales ML, Snyder MP, Chang HY, Greenleaf WJ. Nature 523:486-90, 2015.
4. An integrated cell purification and genomics strategy reveals multiple regulators of pancreas development. Benitez CM, Qu K, Sugiyama T, Pauerstein PT, Liu Y, Tsai J, Gu X, Ghodasara A, Arda HE, Zhang J, Dekker JD, Tucker HO, Chang HY, Kim SK. PLoS Genet 10(10):e1004645, 2014.
5. Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position. Buenrostro JD, Giresi PG, Zaba LC, Chang HY, Greenleaf WJ. Nat Methods 10:1213-8, 2013.
6. Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters. Hung T, Wang Y, Lin MF, Koegel AK, Kotake Y, Grant GD, Horlings HM, Shah N, Umbricht C, Wang P, Wang Y, Kong B, Langerød A, Børresen-Dale AL, Kim SK, van de Vijver M, Sukumar S, Whitfield ML, Kellis M, Xiong Y, Wong DJ, Chang HY. Nat Genet 43:621-9, 2011.