Judith Shizuru, MD, PhD, Professor, Department of Medicine, Division of Blood and Marrow Transplantation, Stanford University School of Medicine
Research Description: Dr. Shizuru’s research focuses on the use blood stem transplantation to induce immune tolerance to transplanted organs and for the treatment of autoimmune diseases, including a long-standing interest in type 1 diabetes. She has developed strategies to safely achieve engraftment of purified blood forming stem into recipients and has translated many of these concepts to human clinical trials. She is working with Drs. Meyer, Kim and others to establish an islet transplant program at Stanford, which should enable allotolerance trials focused on islet transplantation in type 1 and type 2 diabetes.
Selected relevant publications: (Stanford DRC Members in BOLD):
1. Induced immune tolerance for kidney transplantation. 2011. Scandling JD, Busque S, Shizuru JA, Engleman EG, Strober S. N Engl J Med. 365:1359-60.
2. B6.g7 mice reconstituted with BDC2·5 non-obese diabetic (BDC2·5NOD) stem cells do not develop autoimmune diabetes. 2013. Rajasekaran N, Wang N, Hang Y, Macaubas C, Rinderknecht C, Beilhack GF, Shizuru JA, Mellins ED. Clin Exp Immunol. 174:27-37.
3. Chimerism, graft survival, and withdrawal of immunosuppressive drugs in HLA matched and mismatched patients after living donor kidney and hematopoietic cell transplantation. 2015. Scandling JD, Busque S, Shizuru JA, Lowsky R, Hoppe R, Dejbakhsh-Jones S, Jensen K, Shori A, Strober JA, Lavori P, Turnbull BB, Engleman EG, Strober S. Am J Transplant. 15:695-704.
4. Hematopoietic stem cell transplantation in immunocompetent hosts without radiation or chemotherapy. 2016. Chhabra A, Ring AM, Weiskopf K, Schnorr PJ, Gordon S, Le AC, Kwon HS, Ring NG, Volkmer J, Ho PY, Tseng S, Weissman IL, Shizuru JA. Sci Transl Med. 8:351ra105.