Katrin Svensson, Assistant Professor, Pathology, Stanford School of Medicine
Research Description: The overall goal of the Svensson Laboratory is to increase the understanding of how hormones and circulating protein factors regulate energy homeostasis under physiological and pathophysiological conditions. Dr. Svensson’s research program uses an integrated discovery-molecular physiology approach to identify and study orphan hormones involved in regulating energy expenditure and obesity-related disorders such as diabetes and non-alcoholic fatty liver disease. Recently, she has identified circulating proteins with previously unknown functions, and elucidated their role in regulating glucose homeostasis, energy expenditure and insulin resistance. Dr. Svensson's long-term goal is to apply these discoveries toward the development of novel protein therapeutics or biomarkers for metabolic disorders.
Selected relevant publications (Stanford DRC members are in BOLD):
- Svensson, K.J., Long, J.Z., Jedrychowski, M.P., Cohen, P., Lo, J.C., Serag, S., Kir, S., Shinoda, K., Tartaglia, J.A., Rao, R.R., Chédotal, A., Kajimura, S., Gygi, S.P., Spiegelman, B.M. A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function. Cell Metab. 2016 23(3):454-66 PubMed PMCID: PMC4785066.
- Svensson, K.J., Christianson, H.C., Wittrup, A., Bourseau-Guilmain, E., Lindqvist, E., Svensson, L.M., Mörgelin, M., Belting, M. Exosome uptake depends on ERK1/2-heat shock protein 27 signaling and lipid raft-mediated endocytosis negatively regulated by caveolin-1. J Biol Chem. 2013 Jun 14;288(24):17713-24. Epub 2013 May 7. PMCID: PMC3682571.
- Svensson, K.J., Kucharzewska, P., Christianson, H.C., Sköld, S., Löfstedt, T., Johansson, M.C., Mörgelin, M., Bengzon, J., Ruf, W., Belting, M. Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2-mediated heparin-binding EGF signaling in endothelial cells. Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13147-52. PMCID: PMC3156184.