Michael Longaker

Michael T. Longaker, M.D., M.B.A. Deane P. and Louise Mitchell Professor, Department of Surgery, Division of Plastic & Reconstructive Surgery, Stanford University School of Medicine; Professor (by courtesy), Department of Materials Science and Engineering, Stanford University School of Engineering; Co-Director, Institute for Stem Cell Biology and Regenerative Medicine 

Research Description: Dr. Longaker’s diabetes research program over the past 20 years has made important contributions in cranial suture biology, bone tissue engineering, and wound healing. This includes recent work on the effects of diabetes on stem cells in bone. Along with his clinical and research experience, he has directed large research programs at Stanford University for the past 15 years. He is the Director of the Campus-wide Program in Regenerative Medicine with over 150 faculty, and the Co-Director of the Institute for Stem Cell Biology and Regenerative Medicine (SCBRM) which supports the SDRC P&F award program. In summary, Dr. Longaker has demonstrated a record of successful and productive research projects in the areas of skeletal stem cells, adipose-derived stromal cells, craniofacial biology, bone tissue engineering, and wound repair. He is an active participant in the Stanford Diabetes Research Center.

Selected relevant publications (Stanford DRC members in BOLD):

  1. Kosaric N, Srifa W, Bonham CA, Kiwanuka H, Chen K, Kuehlmann BA, Maan ZN, Noishiki C, Porteus MH, Longaker MT, Gurtner GC. Macrophage Subpopulation Dynamics Shift following Intravenous Infusion of Mesenchymal Stromal Cells. Mol Ther. 2020 Sep 2;28(9):2007-2022. doi: 10.1016/j.ymthe.2020.05.022. PMID: 32531238; PMCID: PMC7474342. 

  2. Whittam AJ, Maan ZN, Duscher D, Barrera JA, Hu MS, Fischer LH, Khong S, Kwon SH, Wong VW, Walmsley GG, Giacco F, Januszyk M, Brownlee M, Longaker MT, Gurtner GC. Small molecule inhibition of dipeptidyl peptidase-4 enhances bone marrow progenitor cell function and angiogenesis in diabetic wounds. Transl Res. 2019 Mar;205:51-63. doi: 10.1016/j.trsl.2018.10.006. PMID: 30452888; PMCID: PMC7252504. 

  3. Quarto N, Shailendra S, Meyer NP, Menon S, Renda A, Longaker MT. Twist1-Haploinsufficiency Selectively Enhances the Osteoskeletal Capacity of Mesoderm-Derived Parietal Bone Through Downregulation of Fgf23. Front Physiol. 2018 Oct 15;9:1426. doi: 10.3389/fphys.2018.01426. PMID: 30374308; PMCID: PMC6196243.