Michael Snyder

Michael P. Snyder, PhD Stanford Ascherman Professor and Chair, Department of Genetics; Director, Stanford Center of Genomics and Personalized Medicine, Stanford University School of Medicine


Research Description: Dr. Snyder is a leader in the field of functional genomics and proteomics, and a leader in the ENCODE project. His laboratory study was the first to perform a large-scale functional genomics project in any organism, and has developed many technologies in genomics and proteomics. These technologies have been used for characterizing genomes, proteomes and regulatory networks. He has also combined different state-of–the-art “omics” technologies to perform the first longitudinal detailed integrative personal omics profile (iPOP) of person and used this to assess disease risk and monitor disease states for personalized medicine. He has published studies of diabetes development with these approaches, and collaborates extensively with SDRC investigators, including Drs. Chang, Greenleaf and Kim in diabetes-related research. Based on this experience, Dr. Snyder also serves as the co-director of the Genomics & Analysis Core in the SDRC, and a member of the SDRC Executive Committee.


Selected relevant publications (Stanford DRC members in BOLD):

1.     Arda HE, Li L, Tsai J, Torre EA, Rosli Y, Peiris H, Spitale RC, Dai C, Gu X, Qu K, Wang P, Wang J, Grompe M, Scharfmann R, Snyder MS, Bottino R, Powers AC, Chang HY, Kim SK. Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function. Cell Metab 23:909-20, 2016.

2.     Chennamsetty I, Coronado M, Contrepois K, Keller MP, Carcamo-Orive I, Sandin J, Fajardo G, Whittle AJ, Fathzadeh M, Snyder M, Reaven G, Attie AD, Bernstein D, Quertermous T, Knowles JW. Nat1 Deficiency Is Associated with Mitochondrial Dysfunction and Exercise Intolerance in Mice. Cell Rep 17:527-540, 2016.

3.     Buenrostro JD, Wu B, Litzenburger UM, Ruff D, Gonzales ML, Snyder MP, Chang HY, Greenleaf WJ. Single-cell chromatin accessibility reveals principles of regulatory variation. Nature 523:486-90, 2015.

4.     Buenrostro JD, Araya CL, Chircus LM, Layton CJ, Chang HY, Snyder MP, Greenleaf WJ. Quantitative analysis of RNA-protein interactions on a massively parallel array reveals biophysical and evolutionary landscapes. Nat Biotechnol. 32:562-8, 2014.