The SDRC is committed to uncovering new knowledge and tools to help drive the development of effective therapeutics for diabetes. SDRC supports its investigators financially via a pilot and feasibility grant program to fund original research in diabetes and training programs to help trainees. SDRC members also have access to robust research core services to support their research activities. The SDRC enrichment programs promote active discussion and collaborative efforts among investigators through seminars, affinity group meetings and symposiums. We are proud to announce that our members have published over 50 papers related to diabetes research during this quarter. Here, we recognize some of the ground-breaking publications and findings by our SDRC members (in bold) that have resulted from the direct support of the SDRC. For a full list, please go here.

  1. Ren G, Rezaee M, Razavi M, Taysir A, Wang J, Thakor AS. Adipose tissue-derived mesenchymal stem cells rescue the function of islets transplanted in sub-therapeutic numbers via their angiogenic properties. Cell and Tissue Research 2019. Epub ahead of print.

  2. Sweere JM, Van Bellegehem J, Ishak H, Bach MS, Sunkari V, Kaber G, Manasherob R, Suh G, Popescu M, Marshall PL, Birukova M, Cao X, Katznelson E, Lazzareschi DV, Balaji S, Keswani S, Hawn TR, Secor PR, and Bollyky PL. Filamentous Bacteriophage Suppress Clearance of Bacterial Infection. Science (in press) 2019.

  3. Horton TM, Allegretti PA, Lee S, Moeller HP, Smith M, Annes JP. Zinc-Chelating Small Molecules Preferentially Accumulate and Function within Pancreatic β Cells. Cell Chemical Biology 2019. 26 (2):213-222.

  4. Singh M, Bittner S, Li Y, Bittner A, Han L, Cortez Y, Inayathullah M, Arif Z, Parthasarathi R, Rajadas J, Shen WJ, Nicolls MR, Kraemer FB, Azhar S. Anti-hyperlipidaemic effects of synthetic analogues of nordihydroguaiaretic acid in dyslipidaemic rats. Br J Pharmacol 2019. 176(3): 369-385.

  5. Kahkoska AR, Crandell J, Driscoll KA, Kichler JC, Seid M, Mayer-Davis EJ, Maahs DM. Dysglycemia among youth with type 1 diabetes and suboptimal glycemic control in the Flexible Lifestyle Empowering Change trial. Pediatr Diabetes 2019. 20(2): 180-188.

  6. Azhar S, Bittner S, Hu J, Shen WJ, Cortez Y, Hao X, Han L, Lagerstedt JO, Kraemer FB, Johansson JO. Novel ABCA1 peptide agonists with antidiabetic action. Mol Cell Endocrinol 2019. 15(480): 1-11.

  7. Deng B, Shen WJ, Dong D, Azhar S, Kraemer FB. Plasma membrane cholesterol trafficking in steroidogenesis. FASEB J 2019. 33(1): 1380-1400.

  8. Medina CO, Nagy N, Bollyky PL. Extracellular matrix and the maintenance and loss of peripheral immune tolerance in autoimmune insulitis. Curr Opin Immunol 2018.55: 22-30

  9. Rego S, Dagan-Rosenfeld O, Zhou W, Sailani MR, Limcaoco P, Colbert E, Avina M, Wheeler J, Craig C, Salins D, Röst HL, Dunn J, McLaughlin T, Steinmetz LM, Bernstein JA, Snyder MP. High-frequency actionable pathogenic exome variants in an average-risk cohort. Cold Spring Harb Mol Case Stud 2018. 4(6): a003178.

  10. Iacocca MA, Chora JR, Carrié A, Freiberger T, Leigh SE, Defesche JC,Kurtz CL, DiStefano MT, Santos RD, Humphries SE, Mata P, Jannes CE, Hooper AJ, Wilemon KA, Benlian P, O'Connor R, Garcia J, Wand H,Tichy L, Sijbrands EJ, Hegele RA, Bourbon M, Knowles JW. ClinVar database of global familial hypercholesterolemia-associated DNA variants. Hum Mutat 2018. 39(11): 1631-1640.

  11. DeSalvo DJ, Miller KM, Hermann JM, Maahs DM, Hofer SE, Clements MA, Lilienthal E, Sherr JL, Tauschmann M, Holl RW. Continuous glucose monitoring and glycemic control among youth with type 1 diabetes: International comparison from the T1D Exchange and DPV Initiative. Pediatr Diabetes 2018. 19(7): 1271-1275.

  12. Mahajan A, Taliun D, Thurner M, Robertson NR, Torres JM, Rayner NW, Payne AJ, Steinthorsdottir V, Scott RA, Grarup N, Cook JP, Schmidt EM, Wuttke M, Sarnowski C, Mägi R, Nano J, Gieger C, Trompet S, Lecoeur C, Preuss MH, Prins BP, Guo X, Bielak LF, Below JE, Bowden DW, Chambers JC, Kim YJ, Ng MCY, Petty LE, Sim X, Zhang W, Bennett AJ, Bork-Jensen J, Brummett CM, Canouil M, Ec Kardt KU, Fischer K, Kardia SLR, Kronenberg F, Läll K, Liu CT, Locke AE, Luan J, Ntalla I, Nylander V, Schönherr S, Schurmann C, Yengo L, Bottinger EP, Brandslund I, Christensen C, Dedoussis G, Florez JC, Ford I, Franco OH, Frayling TM, Giedraitis V, Hackinger S, Hattersley AT, Herder C, Ikram MA, Ingelsson M, Jørgensen ME, Jørgensen T, Kriebel J, Kuusisto J, Ligthart S, Lindgren CM, Linneberg A, Lyssenko V, Mamakou V, Meitinger T, Mohlke KL, Morris AD, Nadkarni G, Pankow JS, Peters A, Sattar N, Stančáková A, Strauch K, Taylor KD, Thorand B, Thorleifsson G, Thorsteinsdottir U, Tuomilehto J, Witte DR, Dupuis J, Peyser PA, Zeggini E, Loos RJF, Froguel P, Ingelsson E, Lind L, Groop L, Laakso M, Collins FS, Jukema JW, Palmer CNA, Grallert H, Metspalu A, Dehghan A, Köttgen A, Abecasis GR, Meigs JB, Rotter JI, Marchini J, Pedersen O, Hansen T, Langenberg C, Wareham NJ, Stefansson K, Gloyn AL, Morris AP, Boehnke M, McCarthy MI. Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. Nat Genet 2018. 50(11): 1505-1513.