Ngan F. Huang, PhD, Assistant Professor, Department of Cardiothoracic Surgery, Stanford University School of Medicine
Research Description: Dr. Huang’s research program has made important contributions in understanding how extracellular microenvironment modulates endothelial cell behavior, in order to translate these basic insights towards cardiovascular tissue engineering and regenerative medicine. Endothelial cell biology and pathology is important to diabetes research, including studies of diabetes complications. She has developed innovative biomaterials and technology for enhancing the survival and angiogenesis of endothelial cells derived from induced pluripotent stem cells. Since the success of tissue engineering is dependent on the functionality of patient-derived stem cells, she also studies stem cells derived from patients (i.e., those with metabolic disorders like diabetes or peripheral arterial disease) to determine the functionality of the stem cells once they are differentiated into endothelial cells. Dr. Huang’s laboratory collaborates with Stanford DRC members to characterize the functionality of endothelial cells derived from induced pluripotent stem cells from patients with insulin resistance, pre-diabetes or diabetes.
Selected relevant publications (Stanford DRC members in BOLD):
1. Hou L, Kim JJ, Woo YJ, Huang NF. Stem Cell-Based Therapies to Promote Angiogenesis in Ischemic Cardiovascular Disease. Am J Physiol Heart Circ Physiol. 310:H455-65, 2016.
2. Nakayama KH, Hong G, Lee JC, Patel J, Edwards B, Zaitseva TS, Paukshto MV, Dai H, Cooke JP, Woo YJ, Huang NF. Aligned-Braided Nanofibrillar Scaffold with Endothelial Cells Enhances Arteriogenesis. ACS Nano 9: 6900–6908, 2015.
3. Hadamitzky C, Zaitseva TS, Bazalova-Carter M, Paukshto MV, Hou L, Strassberg Z, Ferguson J, Matsuura Y, Dash R, Yang PC, Kretchetov S, Vogt PM, Rockson SG, Cooke JP, Huang NF. Aligned nanofibrillar collagen scaffolds - Guiding lymphangiogenesis for treatment of acquired lymphedema. Biomaterials 102:259-67, 2016.