Paul Bollyky

Paul L. Bollyky, MD, PhD, Professor, Department of Medicine, Division of Infectious Diseases, Professor, Department of Microbiology & Immunology, Stanford University School of Medicine 

Research Description: Dr. Bollyky’s lab studies how immune responses are regulated within injured and infected tissues, with an emphasis on autoimmune diabetes and diabetic wounds. His goals are to understand why autoimmunity happens and to develop innovative strategies to promote immune tolerance. His group is a translational immunology lab that works with both human tissues as well as in animal models of diabetes. In addition to his research, Dr. Bollyky is a physician specializing in infectious diseases.

Selected relevant publications (Stanford DRC Members in BOLD):

  1. Marshall PL, Nagy N, Kaber G, Barlow GL, Ramesh A, Xie BJ, Linde MH, Haddock NL, Lester CA, Tran QL, de Vries CR, Hargil A, Malkovskiy AV, Gurevich I, Martinez HA, Kuipers HF, Yadava K, Zhang X, Evanko SP, Gebe JA, Wang X, Vernon RB, de la Motte C, Wight TN, Engleman EG, Krams SM, Meyer EH, Bollyky PL. Hyaluronan synthesis inhibition impairs antigen presentation and delays transplantation rejection. Matrix Biol. 2021 Feb;96:69-86. doi: 10.1016/j.matbio.2020.12.001. PMID: 33290836. 

  2. Nagy N, Kaber G, Kratochvil MJ, Kuipers HF, Ruppert SM, Yadava K, Yang J, Heilshorn SC, Long SA, Pugliese A, Bollyky PL. Weekly injection of IL-2 using an injectable hydrogel reduces autoimmune diabetes incidence in NOD mice. Diabetologia. 2021 Jan;64(1):152-158. doi: 10.1007/s00125-020-05314-1. PMID: 33125521; PMCID: PMC7720893. 

  3. Nagy N, Sunkari VG, Kaber G, Hasbun S, Lam DN, Speake C, Sanda S, McLaughlin TL, Wight TN, Long SR, Bollyky PL. Hyaluronan levels are increased systemically in human type 2 but not type 1 diabetes independently of glycemic control. Matrix Biol. 2019 Jul;80:46-58. doi: 10.1016/j.matbio.2018.09.003. Epub 2018 Sep 6. PMID: 30196101; PMCID: PMC6401354. 

  4. Nagy N, Gurevich I, Kuipers HF, Ruppert SM, Marshall PL, Xie BJ, Sun W, Malkovskiy AV, Rajadas J, Grandoch M, Fischer JW, Frymoyer AR, Kaber G, Bollyky PL. 4-Methylumbelliferyl glucuronide contributes to hyaluronan synthesis inhibition. J Biol Chem. 2019 May 10;294(19):7864-7877. doi: 10.1074/jbc.RA118.006166. PMID: 30914479; PMCID: PMC6514619. 

  5. Nagy N, de la Zerda A, Kaber G, Johnson PY, Hu KH, Kratochvil MJ, Yadava K, Zhao W, Cui Y, Navarro G, Annes JP, Wight TN, Heilshorn SC, Bollyky PL, Butte MJ. Hyaluronan content governs tissue stiffness in pancreatic islet inflammation. J Biol Chem. 2018 Jan 12;293(2):567-578. doi: 10.1074/jbc.RA117.000148. PMID: 29183997; PMCID: PMC5767862.  

  6. Marshall PL, Nagy N, Kaber G, Barlow GL, Ramesh A, Xie BJ, Linde MH, Haddock NL, Lester CA, Tran QL, de Vries CR, Hargil A, Malkovskiy AV, Gurevich I, Martinez HA, Kuipers HF, Yadava K, Zhang X, Evanko SP, Gebe JA, Wang X, Vernon RB, de la Motte C, Wight TN, Engleman EG, Krams SM, Meyer EH, Bollyky PL. Hyaluronan synthesis inhibition impairs antigen presentation and delays transplantation rejection. Matrix Biol. 2021 Feb;96:69-86. doi: 10.1016/j.matbio.2020.12.001. Epub 2020 Dec 5. PMID: 33290836; PMCID: PMC8147171. 

  7. Nagy N, Kaber G, Sunkari VG, Marshall PL, Hargil A, Kuipers HF, Ishak HD, Bogdani M, Hull RL, Grandoch M, Fischer JW, McLaughlin TL, Wight TN, Bollyky PL. Inhibition of hyaluronan synthesis prevents β-cell loss in obesity-associated type 2 diabetes. Matrix Biol. 2023 Nov;123:34-47. doi: 10.1016/j.matbio.2023.09.003. Epub 2023 Sep 30. PMID: 37783236; PMCID: PMC10841470. 

  8. Nagy N, Czepiel KS, Kaber G, Stefanovski D, Hargil A, Pennetzdorfer N, Targ R, Reghupaty SC, Wight TN, Vernon RB, Hull-Meichle RL, Marshall P, Medina CO, Martinez H, Kalinowski A, Paladini RD, Garantziotis S, Knowles JW, Bollyky PL. Hymecromone Promotes Longevity and Insulin Sensitivity in Mice. Cells. 2024 Oct 18;13(20):1727. doi: 10.3390/cells13201727. PMID: 39451245; PMCID: PMC11506560.