The SDRC Pilot and Feasibility program has two main goals: 1) to stimulate innovative clinical and translational research and 2) to encourage collaborative, transdisciplinary work. We are excited to announce the following publications have resulted from pilot projects funded by SDRC. If you have received funding support from SDRC and published the work, please provide the reference to be added here. Please acknowledge specifically the support of SDRC P&F program and award P30DK116074 in your relevant publications.

 Outcomes from Stanford Pilot and Feasibility program:

  1. Li J, Zaslavsky M, Su Y, Guo J, Sikora MJ, van Unen V, Christophersen A, Chiou SH, Chen L, Li J, Ji X, Wilhelmy J, McSween AM, Palanski BA, Mallajosyula VVA, Bracey NA, Dhondalay GKR, Bhamidipati K, Pai J, Kipp LB, Dunn JE, Hauser SL, Oksenberg JR, Satpathy AT, Robinson WH, Dekker CL, Steinmetz LM, Khosla C, Utz PJ, Sollid LM, Chien YH, Heath JR, Fernandez-Becker NQ, Nadeau KC, Saligrama N, Davis MM. KIR+CD8+ T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19. Science. 2022 Apr 15. PMID: 35258337; PMCID: PMC8995031.

  2. Gloudemans MJ, Balliu B, Nachun D, Schnurr TM, Durrant MG, Ingelsson E, Wabitsch M, Quertermous T, Montgomery SB, Knowles JW, Carcamo-Orive I. Integration of genetic colocalizations with physiological and pharmacological perturbations identifies cardiometabolic disease genes. Genome Med. 2022 Mar 15. PMID: 35292083; PMCID: PMC8925074.

  3. Metwally AA, Mehta P, Johnson BS, Nagarjuna A, Snyder MP. COVID-19-Induced New-Onset Diabetes: Trends and Technologies. Diabetes. 2021 Dec. PMID: 34686519; PMCID: PMC8660988.

  4. Tanenbaum ML, Ngo J, Hanes SJ, Basina M, Buckingham BA, Hessler D, Maahs DM, Mulvaney S, Hood KK. ONBOARD: A Feasibility Study of a Telehealth-Based Continuous Glucose Monitoring Adoption Intervention for Adults with Type 1 Diabetes. Diabetes Technol Ther. 2021 Dec. PMID: 34270351.

  5. Razavi M, Wang J, Thakor AS. Localized drug delivery graphene bioscaffolds for cotransplantation of islets and mesenchymal stem cells. Sci Adv. 2021 Nov. PMID: 34788097; PMCID: PMC8597999.

  6. Primavera R, Bellotti E, Di Mascolo D, Di Francesco M, Wang J, Kevadiya BD, De Pascale A, Thakor AS, Decuzzi P. Insulin Granule-Loaded MicroPlates for Modulating Blood Glucose Levels in Type-1 Diabetes. ACS Appl Mater Interfaces. 2021 Nov 17. PMID: 34751556; PMCID: PMC8603355.

  7. Maikawa CL, Chen PC, Vuong ET, Nguyen LT, Mann JL, d'Aquino AI, Lal RA, Maahs DM, Buckingham BA, Appel EA. Ultra-Fast Insulin-Pramlintide Co-Formulation for Improved Glucose Management in Diabetic Rats. Adv Sci (Weinh). 2021 Nov. PMID: 34499434; PMCID: PMC8564421.

  8. Addala A, Zaharieva DP, Gu AJ, Prahalad P, Scheinker D, Buckingham B, Hood KK, Maahs DM. Clinically Serious Hypoglycemia Is Rare and Not Associated With Time-in-range in Youth With New-onset Type 1 Diabetes. J Clin Endocrinol Metab. 2021 Oct 21. PMID: 34265059; PMCID: PMC8530719.

  9. Meis CM, Salzman EE, Maikawa CL, Smith AAA, Mann JL, Grosskopf AK, Appel EA. Self-Assembled, Dilution-Responsive Hydrogels for Enhanced Thermal Stability of Insulin Biopharmaceuticals. ACS Biomater Sci Eng. 2021 Sep 13. PMID: 34510910; PMCID: PMC8441967.

  10. Wu CT, Hilgendorf KI, Bevacqua RJ, Hang Y, Demeter J, Kim SK, Jackson PK. Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion. Genes Dev. 2021 Sep 1. PMID: 34385262; PMCID: PMC8415323.

  11. Maikawa CL, Mann JL, Kannan A, Meis CM, Grosskopf AK, Ou BS, Autzen AAA, Fuller GG, Maahs DM, Appel EA. Engineering Insulin Cold Chain Resilience to Improve Global Access. Biomacromolecules. 2021 Aug 9. PMID: 34213889; PMCID: PMC8627795.

  12. Wu CT, Lidsky PV, Xiao Y, Lee IT, Cheng R, Nakayama T, Jiang S, Demeter J, Bevacqua RJ, Chang CA, Whitener RL, Stalder AK, Zhu B, Chen H, Goltsev Y, Tzankov A, Nayak JV, Nolan GP, Matter MS, Andino R, Jackson PK. SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment. Cell Metab. 2021 Aug 3. PMID: 34081912; PMCID: PMC8130512.

  13. Tanenbaum ML, Zaharieva DP, Addala A, Ngo J, Prahalad P, Leverenz B, New C, Maahs DM, Hood KK. 'I was ready for it at the beginning': Parent experiences with early introduction of continuous glucose monitoring following their child's Type 1 diabetes diagnosis. Diabet Med. 2021 Aug. PMID: 33772862; PMCID: PMC8480902.

  14. Maikawa CL, d'Aquino AI, Vuong ET, Su B, Zou L, Chen PC, Nguyen LT, Autzen AAA, Mann JL, Webber MJ, Appel EA. Affinity-Directed Dynamics of Host-Guest Motifs for Pharmacokinetic Modulation via Supramolecular PEGylation. Biomacromolecules. 2021 Jul 27. PMID: 34314146; PMCID: PMC8627827.

  15. Primavera R, Razavi M, Kevadiya BD, Wang J, Vykunta A, Di Mascolo D, Decuzzi P, Thakor AS. Enhancing islet transplantation using a biocompatible collagen-PDMS bioscaffold enriched with dexamethasone-microplates. Biofabrication. 2021 Apr 7. PMID: 33455953; PMCID: PMC8530023.

  16. Lal RA, Hsu L, Zhang J, Schøndorff PK, Heschel M, Buckingham B. Longevity of the novel ConvaTec infusion set with Lantern technology. Diabetes Obes Metab. 2021 Apr 6. PMID: 33822472.

  17. Lal RA, Maikawa CL, Lewis D, Baker SW, Smith AAA, Roth GA, Gale EC, Stapleton LM, Mann JL, Yu AC, Correa S, Grosskopf AK, Liong CS, Meis CM, Chan D, Garner JP, Maahs DM, Buckingham BA, Appel EA. Full closed loop open-source algorithm performance comparison in pigs with diabetes. Clin Transl Med. 2021 Apr. PMID: 33931977; PMCID: PMC8087942.

  18. Maikawa CL, d'Aquino AI, Lal RA, Buckingham BA, Appel EA. Engineering biopharmaceutical formulations to improve diabetes management. Sci Transl Med. 2021 Jan 27. PMID: 33504649; PMCID: PMC8004356.

  19. Horton TM, Kraemer BR, Annes JP. Protocol for determining zinc-dependent β cell-selective small-molecule delivery in mouse pancreas. STAR Protoc. 2021 Jan 12. PMID: 33490979; PMCID: PMC7806521.

  20. Mann JL, Grosskopf AK, Smith AAA, Appel EA. Highly Branched Polydimethylacrylamide Copolymers as Functional Biomaterials. Biomacromolecules. 2021 Jan 11. PMID: 32786733; PMCID: PMC7805010.

  21. Poudineh M, Maikawa CL, Ma EY, Pan J, Mamerow D, Hang Y, Baker SW, Beirami A, Yoshikawa A, Eisenstein M, Kim S, Vučković J, Appel EA, Soh HT. A fluorescence sandwich immunoassay for the real-time continuous detection of glucose and insulin in live animals. Nat Biomed Eng. 2021 Jan. PMID: 33349659; PMCID: PMC7856282.

  22. Yip L, Fuhlbrigge R, Alkhataybeh R, Fathman CG. Gene Expression Analysis of the Pre-Diabetic Pancreas to Identify Pathogenic Mechanisms and Biomarkers of Type 1 Diabetes. Front Endocrinol (Lausanne). 2020 Dec 23. PMID: 33424774; PMCID: PMC7793767.

  23. Lee IT, Nakayama T, Wu CT, Goltsev Y, Jiang S, Gall PA, Liao CK, Shih LC, Schürch CM, McIlwain DR, Chu P, Borchard NA, Zarabanda D, Dholakia SS, Yang A, Kim D, Chen H, Kanie T, Lin CD, Tsai MH, Phillips KM, Kim R, Overdevest JB, Tyler MA, Yan CH, Lin CF, Lin YT, Bau DT, Tsay GJ, Patel ZM, Tsou YA, Tzankov A, Matter MS, Tai CJ, Yeh TH, Hwang PH, Nolan GP, Nayak JV, Jackson PK. ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs. Nat Commun. 2020 Oct 28. PMID: 33116139; PMCID: PMC7595232.

  24. Razavi M, Primavera R, Kevadiya BD, Wang J, Ullah M, Buchwald P, and Thakor AS. Controlled Nutrient Delivery to Pancreatic Islets Using Polydopamine-Coated Mesoporous Silica Nanoparticles. 2020 Oct 14. PMID: 32909757; PMCID: PMC8121116.

  25. Razavi M, Ren T, Zheng F, Telichko A, Wang J, Dahl JJ, Demirci U & Thakor AS. Facilitating islet transplantation using a three-step approach with mesenchymal stem cells, encapsulation, and pulsed focused ultrasound. 2020 Sep 18. PMID: 32948247; PMCID: PMC7501701.

  26. Lanning M, Shen J, Wasser D, Riddle S, Agustin B, Hood K, Naranjo D. Exposure to Closed Loop Barriers Using Virtual Reality. J Diabetes Sci Technol. 2020 Sep. PMID: 32019329; PMCID: PMC7753868.

  27. Liu DD, Ullah M, Concepcion W, Dahl JJ, Thakor AS. The role of ultrasound in enhancing mesenchymal stromal cell-based therapies. Stem Cells Transl Med. 2020 Aug. PMID: 32157802. PMCID: PMC7381806.

  28. Prahalad P, Zaharieva DP, Addala A, New C, Scheinker D, Desai M, Hood KK, Maahs DM. Improving Clinical Outcomes in Newly Diagnosed Pediatric Type 1 Diabetes: Teamwork, Targets, Technology, and Tight Control-The 4T Study. Front Endocrinol (Lausanne). 2020 Jul 9. PMID: 32733375; PMCID: PMC7363838.

  29. Mann JL, Maikawa CL, Smith AAA, Grosskopf AK, Baker SW, Roth GA, Meis CM, Gale EC, Liong CS, Correa S, Chan D, Stapleton LM, Yu AC, Muir B, Howard S, Postma A, Appel EA. An ultrafast insulin formulation enabled by high-throughput screening of engineered polymeric excipients. Sci Transl Med. 2020 Jul 1. PMID: 32611683; PMCID: PMC7716884.

  30. Maikawa CL, Smith AAA, Zou L, Roth GA, Gale EC, Stapleton LM, Baker SW, Mann JL, Yu AC, Correa S, Grosskopf AK, Liong CS, Meis CM, Chan D, Troxell M, Maahs DM, Buckingham BA, Webber MJ, Appel EA. A co-formulation of supramolecularly stabilized insulin and pramlintide enhances mealtime glucagon suppression in diabetic pigs. Nat Biomed Eng. 2020 May. PMID: 32393892; PMCID: PMC7274092.

  31. Primavera R, Kevadiya BD, Swaminathan G, Wilson RJ, De Pascale A, Decuzzi P, Thakor AS. Emerging Nano- and Micro-Technologies Used in the Treatment of Type-1 Diabetes. Nanomaterials (Basel). 2020 Apr 20. PMID: 32325974; PMCID: PMC7221526.

  32. Razavi M, Primavera R, Kevadiya BD, Wang J, Buchwald P, Thakor AS. A Collagen Based Cryogel Bioscaffold that Generates Oxygen for Islet Transplantation. Adv Funct Mater. 2020 Apr 14. PMID: 33071709; PMCID: PMC7567341.

  33. Erkers T, Xie BJ, Kenyon L, Rieck M, Jensen K, Ji X, Basina M, Strober S, Negrin RS, MAecker HT, Meyer EH. High-Parametric Evaluation of Human Invariant Natural Killer T Cells to Delineate Heterogeneity in Allo- and Autoimmunity. Blood. 2020 Mar 12. PMID: 31935280; PMCID: PMC7068034.

  34. Razavi M, Zheng F, Telichko A, Ullah M, Dahl J, Thakor AS. Effect of Pulsed Focused Ultrasound on the Native Pancreas. Ultrasound Med Biol. 2020 Mar. PMID: 31882169; PMCID: PMC7010559.

  35. Allegretti PA, Horton TM, Abdolazimi Y, Moeller HP, Yeh B, Caffet M, Michel G, Smith M, Annes JP. Generation of highly potent DYRK1A-dependent inducers of human β-Cell replication via Multi-Dimensional compound optimization. Bioorg Med Chem. 2020 Jan 1. PMID: 31757680; PMCID: PMC6941846.

  36. Prahalad P, Addala A, Scheinker D, Hood KK, Maahs DM. CGM Initiation Soon After Type 1 Diabetes Diagnosis Results in Sustained CGM Use and Wear Time. Diabetes Care. 2020 Jan. PMID: 31558548; PMCID: PMC7011198.

  37. Maikawa CL, Smith AAA, Zou L, Meis CM, Mann JL, Webber MJ, Appel EA. Stable Monomeric Insulin Formulations Enabled by Supramolecular PEGylation of Insulin Analogues. Adv Ther (Weinh). 2020 Jan. PMID: 32190729; PMCID: PMC7079736.

  38. Razavi M, Zheng F, Telichko A, Wang J, Ren G, Dahl J, Thakor AS. Improving the Function and Engraftment of Transplanted Pancreatic Islets Using Pulsed Focused Ultrasound Therapy. Sci Rep. 2019 Sep 16. PMID: 31527773; PMCID: PMC6746980.

  39. Nagy N, Sunkari VG, Kaber G, Hasbun S, Lam DN, Speake C, Sanda S, McLaughlin TL, Wight TN, Long SR, Bollyky PL. Hyaluronan levels are increased systemically in human type 2 but not type 1 diabetes independently of glycemic control. Matrix Biol. 2019 Jul. PMID: 30196101; PMCID: PMC6401354.

  40. Lee WH, Ong SG, Zhou Y, Tian L, Bae HR, Baker N, Whitlatch A, Mohammadi L, Guo H, Nadeau KC, Springer ML, Schick SF, Bhatnagar A, Wu JC. Modeling Cardiovascular Risks of E-Cigarettes With Human-Induced Pluripotent Stem Cell-Derived Endothelial Cells. J Am Coll Cardiol. 2019 Jun 4. PMID: 31146818; PMCID: PMC6637948.

  41. Ren G, Rezaee M, Razavi M, Taysir A, Wang J, Thakor AS. Adipose tissue-derived mesenchymal stem cells rescue the function of islets transplanted in sub-therapeutic numbers via their angiogenic properties. Cell and Tissue Research. 2019 Jun. PMID: 30707291; PMCID: PMC6615057.

  42. Nagy N, Gurevich I, Kuipers HF, Ruppert SM, Marshall PL, Xie BJ, Sun W, Malkovskiy AV, Rajadas J, Grandoch M, Fischer JW, Frymoyer AR, Kaber G, Bollyky PL. 4-Methylumbelliferyl glucuronide contributes to hyaluronan synthesis inhibition. J Biol Chem. 2019 May 10. PMID: 30914479; PMCID: PMC6514619.

  43. Ong SB, Lee WH, Shao NY, Ismail NI, Katwadi K, Lim MM, Kwek XY, Michel NA, Li J, Newson J, Tahmasebi S, Rehman J, Kodo K, Jang HR, Ong SG. Calpain Inhibition Restores Autophagy and Prevents Mitochondrial Fragmentation in a Human iPSC Model of Diabetic Endotheliopathy. Stem Cell Reports. 2019 Mar 5. PMID: 30799273; PMCID: PMC6411483.

  44. Horton TM, Allegretti PA, Lee S, Moeller HP, Smith M, Annes JP. Zinc-chelating small molecules preferentially accumulate and function within pancreatic β cells. Cell Chemical Biology. 2019 Feb 21. PMID: 30527998; PMCID: PMC6386607.

  45. Medina CO, Nagy N, Bollyky PL. Extracellular matrix and the maintenance and loss of peripheral immune tolerance in autoimmune insulitis. Curr Opin Immunol 2018 Dec. PMID: 30248522; PMCID: PMC6286219.

  46. Abdolazimi Y, Zhao Z, Lee S, Xu H, Allegretti P, Horton TM, Yeh B, Moeller HP, Nichols RJ, McCutcheon D, Shalizi A, Smith M, Armstrong NA, Annes JP. CC-401 Promotes β-Cell Replication via Pleiotropic Consequences of DYRK1A/B Inhibition. Endocrinology. 2018 Sep 1. PMID: 29514186; PMCID: PMC6287593.

  47. Bahrami-Nejad Z, Zhao ML, Tholen S, Hunerdosse D, Tkach KE, van Schie S, Chung M, Teruel MN. A Transcriptional Circuit Filters Oscillating Circadian Hormonal Inputs to Regulate Fat Cell Differentiation. Cell Metab. 2018 Apr 3. PMID: 29617644; PMCID: PMC5889123.

  48. Nagy N, de La Zerda A, Kaber G, Johnson PY, Hu KH, Kratochvil MJ, Yadava K, Zhao W, Cui Y, Navarro G, Annes JP, Wight TN, Heilshorn SC, Bollyky PL, Butte MJ. Hyaluronan content governs tissue stiffness in pancreatic islet inflammation. J Biol Chem. 2018 Jan 12. PMID: 29183997; PMCID: PMC5767862.

 Outcomes from Regional Pilot and Feasibility program:

  1. Jung BC, Kang S. Epigenetic regulation of inflammatory factors in adipose tissue. Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Nov. PMID: 34332076; PMCID: PMC8719460.