The mission of the Stanford Islet Research Core is to provide access to quality islets from mouse, pig and humans as well as technical support for islet transplantation among other services. We are glad to note that this mission has been successful in the following projects leading to publications listed below!
Islet cell replacement and transplantation immunology in a mouse strain with inducible diabetes. Bhagchandani P, Chang CA, Zhao W, Ghila L, Herrera PL, Chera S, Kim SK. Sci Rep. 2022 May 31;12(1):9033. doi: 10.1038/s41598-022-13087-3. PMID: 35641781; PMCID: PMC9156753.
Localized drug delivery graphene bioscaffolds for cotransplantation of islets and mesenchymal stem cells. Razavi M, Wang J, Thakor AS. Sci Adv. 2021 Nov 19;7(47):eabf9221. doi: 10.1126/sciadv.abf9221. Epub 2021 Nov 17. PMID: 34788097; PMCID: PMC8597999.
SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment.Wu CT, Lidsky PV, Xiao Y, Lee IT, Cheng R, Nakayama T, Jiang S, Demeter J, Bevacqua RJ, Chang CA, Whitener RL, Stalder AK, Zhu B, Chen H, Goltsev Y, Tzankov A, Nayak JV, Nolan GP, Matter MS, Andino R, Jackson PK. Cell Metab. 2021 Aug 3;33(8):1565-1576.e5. doi: 10.1016/j.cmet.2021.05.013. Epub 2021 May 18. PMID: 34081912; PMCID: PMC8130512.
Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion. Wu CT, Hilgendorf KI, Bevacqua RJ, Hang Y, Demeter J, Kim SK, Jackson PK. Genes Dev. 2021 Sep 1;35(17-18):1243-1255. doi: 10.1101/gad.348261.121. Epub 2021 Aug 12. PMID: 34385262; PMCID: PMC8415323.
An Organoid Archetype for Metabolism Research. Diabetes. Friedlander MSH, Nguyen VM, Kim SK, Bevacqua RJ. Pancreatic Pseudoislets: 2021 May;70(5):1051-1060. doi: 10.2337/db20-1115. Epub 2021 May 4. PMID: 33947722; PMCID: PMC8343609.
Enhancing islet transplantation using a biocompatible collagen-PDMS bioscaffold enriched with dexamethasone-microplates. Primavera R, Razavi M, Kevadiya BD, Wang J, Vykunta A, Di Mascolo D, Decuzzi P, Thakor AS. Biofabrication. 2021 Apr 7;13(3):10.1088/1758-5090/abdcac. doi: 10.1088/1758-5090/abdcac. PMID: 33455953; PMCID: PMC8530023.
Using a barcoded AAV capsid library to select for clinically relevant gene therapy vectors. Pekrun K, De Alencastro G, Luo QJ, Liu J, Kim Y, Nygaard S, Galivo F, Zhang F, Song R, Tiffany MR, Xu J, Hebrok M, Grompe M, Kay MA. JCI Insights; 2019. PMID: 31723052.
Zinc-chelating small molecules preferentially accumulate and function within pancreatic β cells. Horton TM, Allegretti PA, Lee S, Moeller HP, Smith M, Annes JP. Cell Chem Biol (2018 Nov 16); pii: S2451-9456(18)30379-9.
Spheroid Culture of Human Pancreatic Ductal Cells to Reconstitute Development of Pancreatic Intraepithelial Neoplasia. Lee JJ and Kim SK. Methods Molecular Biology, 1882: 62-71. doi 10.1007/978-1-4939-8879-2_6. PMID: 30378044
Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris. The Tabula Muris Consortium. Nature (2018 Oct 18) 562: 367. doi 10.1038/s41586-018-0590-4. PMID: 30283141
Discovering Human Diabetes-Risk Gene Function with Genetics and Physiological Assays. Peiris H, Park S, Louis S, Gu X, Lam JY, Asplund O, Ippolito GC, Bottino R, Groop L, Tucker H, Kim SK. Nature Communications (2018 Sep 21) 9(1):3855. Doi 10.1038/s41467-018-06249-3. PMID: 30242153
A Chromatin Basis for Cell Lineage and Disease Risk in the Human Pancreas. Arda HE, Tsai J, Rosli YR, Giresi P, Bottino R, Greenleaf WJ, Chang HY, Kim SK. Cell Systems (2018 Sep 26)7(3):310-322.e4. doi: 10.1016/j.cels.2018.07.007. Epub 2018 Aug 22. PMID: 30145115
We request our users to please thank the Stanford Islet Research Core in all publications that result from our services. The following language may be used:
“Data was obtained using the services of the Stanford Islet Research Core facility in the Stanford Diabetes Research Center (P30DK116074).”