The mission of the Stanford Islet Research Core is to provide access to quality islets from mouse, pig and humans as well as technical support for islet transplantation among other services. We are glad to note that this mission has been successful in the following projects leading to publications listed below!
Precision Delivery of Human Bone Marrow-Derived Mesenchymal Stem Cells Into the Pancreas Via Intra-arterial Injection Prevents the Onset of Diabetes. Primavera R, Regmi S, Yarani R, Levitte S, Wang J, Ganguly A, Chetty S, Guindani M, Ricordi C, Meyer E, Thakor AS. Stem Cells Transl Med. 2024 Jun 14;13(6):559-571. doi: 10.1093/stcltm/szae020. PMID: 38530131; PMCID: PMC11165159.
RFX6 Maintains Gene Expression and Function of Adult Human Islet α-Cells. Coykendall VMN, Qian MF, Tellez K, Bautista A, Bevacqua RJ, Gu X, Hang Y, Neukam M, Zhao W, Chang C, MacDonald PE, Kim SK. Diabetes. 2024 Mar 1;73(3):448-460. doi: 10.2337/db23-0483. PMID: 38064570; PMCID: PMC10882151.
A PTER-dependent pathway of taurine metabolism linked to energy balance. Wei W, Lyu X, Markhard AL, Fu S, Mardjuki RE, Cavanagh PE, Zeng X, Rajniak J, Lu N, Xiao S, Zhao M, Moya-Garzon MD, Truong SD, Chou JC, Wat LW, Chidambaranathan-Reghupaty S, Coassolo L, Xu D, Shen F, Huang W, Ramirez CB, Jang C, Svensson KJ, Fischbach MA, Long JZ. bioRxiv [Preprint]. 2024 Mar 22:2024.03.21.586194. doi: 10.1101/2024.03.21.586194. PMID: 38562797; PMCID: PMC10983888.
Sensitization of cancer cells to ferroptosis coincident with cell cycle arrest. Rodencal J, Kim N, He A, Li VL, Lange M, He J, Tarangelo A, Schafer ZT, Olzmann JA, Long JZ, Sage J, Dixon SJ. Cell Chem Biol. 2024 Feb 15;31(2):234-248.e13. doi: 10.1016/j.chembiol.2023.10.011. Epub 2023 Nov 13. PMID: 37963466; PMCID: PMC10925838.
A class of secreted mammalian peptides with potential to expand cell-cell communication. Wiggenhorn AL, Abuzaid HZ, Coassolo L, Li VL, Tanzo JT, Wei W, Lyu X, Svensson KJ, Long JZ. Nat Commun. 2023 Dec 8;14(1):8125. doi: 10.1038/s41467-023-43857-0. PMID: 38065934; PMCID: PMC10709327.
An organism-wide atlas of hormonal signaling based on the mouse lemur single-cell transcriptome. Liu S, Ezran C, Wang MFZ, Li Z, Awayan K; Tabula Microcebus Consortium; Long JZ, De Vlaminck I, Wang S, Epelbaum J, Kuo CS, Terrien J, Krasnow MA, Ferrell JE Jr. Nat Commun. 2024 Mar 11;15(1):2188. doi: 10.1038/s41467-024-46070-9. PMID: 38467625; PMCID: PMC10928088.
HNF1α maintains pancreatic α and β cell functions in primary human islets. Qian MF, Bevacqua RJ, Coykendall VM, Liu X, Zhao W, Chang CA, Gu X, Dai XQ, MacDonald PE, Kim SK. JCI Insight. 2023 Dec 22;8(24):e170884. doi: 10.1172/jci.insight.170884. PMID: 37943614; PMCID: PMC10807710.
Inhibition of hyaluronan synthesis prevents β-cell loss in obesity-associated type 2 diabetes. Nagy N, Kaber G, Sunkari VG, Marshall PL, Hargil A, Kuipers HF, Ishak HD, Bogdani M, Hull RL, Grandoch M, Fischer JW, McLaughlin TL, Wight TN, Bollyky PL. Matrix Biol. 2023 Nov;123:34-47. doi: 10.1016/j.matbio.2023.09.003. Epub 2023 Sep 30. PMID: 37783236; PMCID: PMC10841470.
PAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell development. Lau HH, Krentz NAJ, Abaitua F, Perez-Alcantara M, Chan JW, Ajeian J, Ghosh S, Lee Y, Yang J, Thaman S, Champon B, Sun H, Jha A, Hoon S, Tan NS, Gardner DS, Kao SL, Tai ES, Gloyn AL, Teo AKK. Nat Commun. 2023 Sep 30;14(1):6119. doi: 10.1038/s41467-023-41860-z. PMID: 37777536; PMCID: PMC10542369.
Multiplexed CRISPR gene editing in primary human islet cells with Cas9 ribonucleoprotein. Bevacqua RJ, Zhao W, Merheb E, Kim SH, Marson A, Gloyn AL, Kim SK. bioRxiv [Preprint]. 2023 Sep 17:2023.09.16.558090. doi: 10.1101/2023.09.16.558090. Update in: iScience. 2023 Dec 08;27(1):108693. doi: 10.1016/j.isci.2023.108693. PMID: 37745551; PMCID: PMC10516051.
A human TRPV1 genetic variant within the channel gating domain regulates pain sensitivity in rodents. He S, Zambelli VO, Sinharoy P, Brabenec L, Bian Y, Rwere F, Hell RC, Stein Neto B, Hung B, Yu X, Zhao M, Luo Z, Wu C, Xu L, Svensson KJ, McAllister SL, Stary CM, Wagner NM, Zhang Y, Gross ER. J Clin Invest. 2023 Feb 1;133(3):e163735. doi: 10.1172/JCI163735. PMID: 36472910; PMCID: PMC9888391.
Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression. Mattis KK, Krentz NAJ, Metzendorf C, Abaitua F, Spigelman AF, Sun H, Ikle JM, Thaman S, Rottner AK, Bautista A, Mazzaferro E, Perez-Alcantara M, Manning Fox JE, Torres JM, Wesolowska-Andersen A, Yu GZ, Mahajan A, Larsson A, MacDonald PE, Davies B, den Hoed M, Gloyn AL. Diabetologia. 2023 Apr;66(4):674-694. doi: 10.1007/s00125-022-05856-6. Epub 2023 Jan 12. PMID: 36633628; PMCID: PMC9947029.
Curative islet and hematopoietic cell transplantation in diabetic mice without toxic bone marrow conditioning. Chang CA, Bhagchandani P, Poyser J, Velasco BJ, Zhao W, Kwon HS, Meyer E, Shizuru JA, Kim SK. Cell Rep. 2022 Nov 8;41(6):111615. doi: 10.1016/j.celrep.2022.111615. PMID: 36351397; PMCID: PMC9922474.
Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1. Zhao M, Banhos Danneskiold-Samsøe N, Ulicna L, Nguyen Q, Voilquin L, Lee DE, White JP, Jiang Z, Cuthbert N, Paramasivam S, Bielczyk-Maczynska E, Van Rechem C, Svensson KJ. Elife. 2022 Sep 28;11:e80014. doi: 10.7554/eLife.80014. PMID: 36169399; PMCID: PMC9592085.
Islet cell replacement and transplantation immunology in a mouse strain with inducible diabetes. Bhagchandani P, Chang CA, Zhao W, Ghila L, Herrera PL, Chera S, Kim SK. Sci Rep. 2022 May 31;12(1):9033. doi: 10.1038/s41598-022-13087-3. PMID: 35641781; PMCID: PMC9156753.
Localized drug delivery graphene bioscaffolds for cotransplantation of islets and mesenchymal stem cells. Razavi M, Wang J, Thakor AS. Sci Adv. 2021 Nov 19;7(47):eabf9221. doi: 10.1126/sciadv.abf9221. Epub 2021 Nov 17. PMID: 34788097; PMCID: PMC8597999.
SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment.Wu CT, Lidsky PV, Xiao Y, Lee IT, Cheng R, Nakayama T, Jiang S, Demeter J, Bevacqua RJ, Chang CA, Whitener RL, Stalder AK, Zhu B, Chen H, Goltsev Y, Tzankov A, Nayak JV, Nolan GP, Matter MS, Andino R, Jackson PK. Cell Metab. 2021 Aug 3;33(8):1565-1576.e5. doi: 10.1016/j.cmet.2021.05.013. Epub 2021 May 18. PMID: 34081912; PMCID: PMC8130512.
Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion. Wu CT, Hilgendorf KI, Bevacqua RJ, Hang Y, Demeter J, Kim SK, Jackson PK. Genes Dev. 2021 Sep 1;35(17-18):1243-1255. doi: 10.1101/gad.348261.121. Epub 2021 Aug 12. PMID: 34385262; PMCID: PMC8415323.
An Organoid Archetype for Metabolism Research. Diabetes. Friedlander MSH, Nguyen VM, Kim SK, Bevacqua RJ. Pancreatic Pseudoislets: 2021 May;70(5):1051-1060. doi: 10.2337/db20-1115. Epub 2021 May 4. PMID: 33947722; PMCID: PMC8343609.
Enhancing islet transplantation using a biocompatible collagen-PDMS bioscaffold enriched with dexamethasone-microplates. Primavera R, Razavi M, Kevadiya BD, Wang J, Vykunta A, Di Mascolo D, Decuzzi P, Thakor AS. Biofabrication. 2021 Apr 7;13(3):10.1088/1758-5090/abdcac. doi: 10.1088/1758-5090/abdcac. PMID: 33455953; PMCID: PMC8530023.
Cell of Origin Influences Pancreatic Cancer Subtype. Flowers BM, Xu H, Mulligan AS, Hanson KJ, Seoane JA, Vogel H, Curtis C, Wood LD, Attardi LD. Cancer Discov. 2021 Mar;11(3):660-677. doi: 10.1158/2159-8290.CD-20-0633. PMID: 34009137; PMCID: PMC8134763.
Single-Nucleus and In Situ RNA-Sequencing Reveal Cell Topographies in the Human Pancreas. Tosti L, Hang Y, Debnath O, Tiesmeyer S, Trefzer T, Steiger K, Ten FW, Lukassen S, Ballke S, Kühl AA, Spieckermann S, Bottino R, Ishaque N, Weichert W, Kim SK, Eils R, Conrad C. Gastroenterology. 2021 Mar;160(4):1330-1344.e11. doi: 10.1053/j.gastro.2020.11.010. Epub 2020 Nov 16. PMID: 33212097.
Using a barcoded AAV capsid library to select for clinically relevant gene therapy vectors. Pekrun K, De Alencastro G, Luo QJ, Liu J, Kim Y, Nygaard S, Galivo F, Zhang F, Song R, Tiffany MR, Xu J, Hebrok M, Grompe M, Kay MA. JCI Insights; 2019. PMID: 31723052.
Zinc-chelating small molecules preferentially accumulate and function within pancreatic β cells. Horton TM, Allegretti PA, Lee S, Moeller HP, Smith M, Annes JP. Cell Chem Biol (2018 Nov 16); pii: S2451-9456(18)30379-9.
Spheroid Culture of Human Pancreatic Ductal Cells to Reconstitute Development of Pancreatic Intraepithelial Neoplasia. Lee JJ and Kim SK. Methods Molecular Biology, 1882: 62-71. doi 10.1007/978-1-4939-8879-2_6. PMID: 30378044
Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris. The Tabula Muris Consortium. Nature (2018 Oct 18) 562: 367. doi 10.1038/s41586-018-0590-4. PMID: 30283141
Discovering Human Diabetes-Risk Gene Function with Genetics and Physiological Assays. Peiris H, Park S, Louis S, Gu X, Lam JY, Asplund O, Ippolito GC, Bottino R, Groop L, Tucker H, Kim SK. Nature Communications (2018 Sep 21) 9(1):3855. Doi 10.1038/s41467-018-06249-3. PMID: 30242153
A Chromatin Basis for Cell Lineage and Disease Risk in the Human Pancreas. Arda HE, Tsai J, Rosli YR, Giresi P, Bottino R, Greenleaf WJ, Chang HY, Kim SK. Cell Systems (2018 Sep 26)7(3):310-322.e4. doi: 10.1016/j.cels.2018.07.007. Epub 2018 Aug 22. PMID: 30145115
We request our users to please thank the Stanford Islet Research Core in all publications that result from our services. The following language may be used:
“Data was obtained using the services of the Stanford Islet Research Core facility in the Stanford Diabetes Research Center (P30DK116074).”