Sean Wu

Sean M. Wu, MD, PhD, Professor, Department of Medicine, Division of Cardiovascular Medicine; Professor (by courtesy), Department of Pediatrics, Stanford University School of Medicine

Research Description: Dr. Sean Wu’s research program has been dedicated to making fundamental discoveries in developmental and stem cell biology of the cardiovascular system as well as genetic and environmentally-mediated factors that that impact the development of cardiovascular diseases. He has established significant expertise in the isolation and characterization of cardiovascular stem/progenitor cells and has acquired tremendous experience and resources for working with induced pluripotent stem cell (iPSCs) models of diseases including cardiometabolic diseases. His research projects on cardiac development, cardio- metabolic disease modeling, and more recently, cardiovascular tissue engineering are supported by a number of awards including the NIH Director’s New Innovator Award, NIH Director’s Pioneer Award, the NHLBI Progenitor Cell Biology Consortium, the California Institute of Regenerative Medicine, collaborating NIH R01s grants, grants from the American Heart Association, among others.

Selected relevant publications (Stanford DRC Members in BOLD):

  1. Hwang HV, Sandeep N, Paige SL, Ranjbarvaziri S, Hu DQ, Zhao M, Lan IS, Coronado M, Kooiker KB, Wu SM, Fajardo G, Bernstein D, Reddy S. 4HNE Impairs Myocardial Bioenergetics in Congenital Heart Disease-Induced Right Ventricular Failure. Circulation. 2020 Oct 27;142(17):1667-1683. doi: 10.1161/CIRCULATIONAHA.120.045470. PMID: 32806952; PMCID: PMC7606813. 

  2. Puluca N, Lee S, Doppler S, Münsterer A, Dreßen M, Krane M, Wu SM. Bioprinting Approaches to Engineering Vascularized 3D Cardiac Tissues. Curr Cardiol Rep. 2019 Jul 27;21(9):90. doi: 10.1007/s11886-019-1179-8. PMID: 31352612; PMCID: PMC7340624. 

  3. Paik DT, Tian L, Lee J, Sayed N, Chen IY, Rhee S, Rhee JW, Kim Y, Wirka RC, Buikema JW, Wu SM, Red-Horse K, Quertermous T, Wu JC. Large-Scale Single-Cell RNA-Seq Reveals Molecular Signatures of Heterogeneous Populations of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells. Circ Res. 2018 Aug 3;123(4):443-450. doi: 10.1161/CIRCRESAHA.118.312913. PMID: 29986945; PMCID: PMC6202208. 

  4. Stanley G, Sinha R, D'Amato G, Das S, Rhee S, Chang AH, Poduri A, Raftrey B, Dinh TT, Roper WA, Li G, Quinn KE, Caron KM, Wu SM, Miquerol L, Butcher EC, Weissman I, Quake S, Red-Horse K. Single-cell analysis of early progenitor cells that build coronary arteries. Nature. 2018 Jul;559(7714):356-362. doi: 10.1038/s41586-018-0288-7. PMID: 29973725; PMCID: PMC6053322.