Seung Kim

Seung K. Kim, MD, PhD, KM Mulberry Professor, Department of Developmental Biology; Professor (by courtesy), Department of Medicine, Division of Endocrinology, Gerontology & Metabolism; Professor (by courtesy), Department of Pediatrics, Stanford University School of Medicine 

Research Description: Dr. Kim’s diabetes research program over the past quarter century has made important contributions to understanding pancreatic islet development and biology in several models, including fruit flies, mice, pigs and humans. He has innovated methods for studying pancreas and islet biology in these models, and discovered cellular, molecular and genetic mechanisms governing growth, cell fate and development and function of endocrine and exocrine cells in mouse and human pancreas. His collaborations in these areas are extensive and productive. Dr. Kim leads or has led multi- investigator research and training programs, including in the NIDDK Human Islet Resource Network (HIRN), and the Accelerating Medicines Partnership-T2D (AMP-T2D) consortium, and has served as SDRC Director since 2016.

Selected relevant publications (Stanford DRC members in BOLD):

  1. Tellez K, Hang Y, Gu X, Chang CA, Stein RW, Kim SK. In vivo studies of glucagon secretion by human islets transplanted in mice. Nat Metab. 2020 Jun;2(6):547-557. PMID: 32694729; PMCID: PMC7739959. 

  2. Camunas-Soler J, Dai XQ, Hang Y, Bautista A, Lyon J, Suzuki K, Kim SK, Quake SR, MacDonald PE. Patch-Seq Links Single-Cell Transcriptomes to Human Islet Dysfunction in Diabetes. Cell Metab. 2020 May 5;31(5):1017-1031.e4. PMID: 32302527; PMCID: PMC7398125. 

  3. Kim S, Whitener RL, Peiris H, Gu X, Chang CA, Lam JY, Camunas-Soler J, Park I, Bevacqua RJ, Tellez K, Quake SR, Lakey JRT, Bottino R, Ross PJ, Kim SK. Molecular and genetic regulation of pig pancreatic islet cell development. Development. 2020 Mar 30;147(6):dev186213. PMID: 32108026; PMCID: PMC7132804. 

  4. Arda HE, Tsai J, Rosli YR, Giresi P, Bottino R, Greenleaf WJ, Chang HY, Kim SK. A Chromatin Basis for Cell Lineage and Disease Risk in the Human Pancreas. Cell Syst. 2018 Sep 26;7(3):310-322.e4. PMID: 30145115; PMCID: PMC6347013. 

  5. M. Enge, Arda, HE, Mignardi, M, Beausang, J, Bottino, R, S.K. Kim, and S.R. Quake. 2017. Single cell transcriptome analysis of human pancreas reveals transcriptional signatures of aging and somatic mutation patterns. Cell 171:321-330. PMID: 28965763; PMCID: PMC6047899.