Siddharth Krishnan

Siddharth Krishnan, PhD, Assistant Professor, Department of Electrical Engineering, Stanford University

Research Description: Dr. Krishnan is an Assistant Professor of Electrical Engineering at Stanford University, with a strong track record in bioelectronic device innovation. He previously served as a K99-funded Research Scientist in the labs of Professors Daniel Anderson and Robert Langer at MIT and Boston Children’s Hospital. He earned his BS and MS from Washington University in St. Louis and completed his PhD in Professor John Rogers’ lab at the University of Illinois at Urbana-Champaign. His work focuses on translational bioelectronic systems for sensing and therapeutics.

Dr. Krishnan’s research includes three diabetes-focused projects aligned with the SDRC’s mission:

1. Type 1 Diabetes: Development of bioelectronic devices for immunosuppression-free transplantation of insulin-producing islets, designed for subcutaneous delivery with high-density loading.

2. Type 2 Diabetes: Use of engineered, GLP-1-secreting cell implants as long-term alternatives to drug-based glycemic control.

3. Hypoglycemia: Wireless-triggered delivery of stable, dry-powder glucagon via implantable devices, with future integration into closed-loop glucose monitoring systems.

His multidisciplinary approach integrates electronics, materials science, and cell engineering to advance next-generation diabetes therapies.

Selected relevant publications (Stanford DRC members are in BOLD)

  1. Krishnan SR, O'Keeffe L, Rudra A, Gumustop D, Khatib N, Liu C, Yang J, Wang A, Bochenek MA, Lu YC, Bose S, Reed K, Langer R, Anderson DG. “Emergency delivery of particulate drugs by active ejection using in vivo wireless devices”. Nat Biomed Eng. 2025 Jul 9. doi: 10.1038/s41551-025-01436-2. Epub ahead of print. PMID: 40634646.

  2. Krishnan, S.R., Langer, R., Anderson, D.G., Materials approaches for next-generation encapsulated cell therapies. MRS Communications (2024): 1-13.

  3. Krishnan, S.R., Liu, C., Bochenek, M.A, Bose, S., Khatib, N., Walters, B., O’Keeffe, L., Facklam, A., Langer, R., Anderson, D.G., A wireless, battery-free device enables oxygen generation and immune protection of therapeutic xenotransplants, in vivo. Proceedings of the National Academy of Sciences, 120 (40) e2311707120, 2023.