Tandy Aye, MD, Associate Professor, Departments of Pediatrics and (by Courtesy) Psychiatry and Behavioral Science, Division of Endocrinology and Diabetes, Stanford University School of Medicine
Research Description: The adverse effects of Type 1 diabetes (T1D) on the cardiovascular, renal, ophthalmologic and neurologic systems are well established. Far less is known about the impact of T1D on the developing brain. Dr. Aye has conducted sentinel research demonstrating the adverse effects of both hyper-and hypoglycemia on brain development in young children with T1D and her findings have led to an increased focus on brain development and have contributed to new directions for a national diabetes research consortium, DirecNet. She employs advanced modalities, voxel-based morphometry and diffusion-tensor imaging, in magnetic resonance imaging (MRI). These techniques allow the comparison of specific microstructures of the brains among many brain images and the neuronal connections between these microstructures. Currently she is examining these microstructures in brains of children during and after diabetic ketoacidosis since they are at risk for brain swelling, stroke and coma. She is monitoring their neurocognitive function and non-invasive measurements of brain compliance using a device used to track brain compliance during strokes and concussions and tests of neurocognitive function (Neurowave System, Jan Medical). In addition she is looking at the barriers to diabetes education and self-management that results from the microstructural changes in the brain. Results from Dr. Aye’s neurocognitive studies further support the Division of Pediatric Endocrinology’s mission to develop an artificial pancreas.
Selected relevant publications (Stanford DRC Members in BOLD):
1. Mazaika PK, Weinzimer SA, Mauras N, Buckingham B, White NH, Tsalikian E, Hershey T, Cato A, Aye T, Fox L, Wilson DM, Tansey MJ, Tamborlane W, Peng D, Raman M, Marzelli M, Reiss AL; Diabetes Research in Children Network (DirecNet). Variations in Brain Volume and Growth in Young Children With Type 1 Diabetes. Diabetes 65:476-85, 2016.
2. Calhoun PM, Buckingham BA, Maahs DM, Hramiak I, Wilson DM, Aye T, Clinton P, Chase P, Messer L, Kollman C, Beck RW, Lum J; In Home Closed Loop Study Group. Efficacy of an Overnight Predictive Low-Glucose Suspend System in Relation to Hypoglycemia Risk Factors in Youth and Adults With Type 1 Diabetes. J Diabetes Sci Technol. 2016 Nov 1;10(6):1216-1221.
3. Wadwa RP, Chase HP, Raghinaru D, Buckingham BA, Hramiak I, Maahs DM, Messer L, Ly T, Aye T, Clinton P, Kollman C, Beck RW, Lum J; In Home Closed Loop Study Group.. Ketone production in children with type 1 diabetes, ages 4-14 years, with and without nocturnal insulin pump suspension. Pediatr Diabetes. 2016 Jul 12. doi: 10.1111/pedi.12410. PMCID: PMC5233607