Tim Assimes

Themistocles L. Assimes, MD, PhD, Assistant Professor, Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine


Research Description: Dr. Assimes’ research program over the past 10 years has made important contributions to our understanding of the genetic and non-genetic determinants of insulin resistance as well as on the relationship between diabetes, insulin resistance and the risk of atherosclerosis related outcomes.  These contributions have been made through his involvement in large scale genome wide association studies of direct and surrogate measures of insulin resistance, type 2 diabetes, as well coronary heart disease in both European and East Asian populations. He has also leveraged large scale genomic studies to conduct instrumental variable analyses that shed light on the causal vs. non-causal nature of these relationships.


Selected relevant publications (Stanford DRC Members in BOLD):

1.         Knowles JW, Xie W, Zhang Z, Chennamsetty I, Assimes TL, [11 authors], Abbasi F, [6 authors], Tsao PS; [11 authors/consortia] Ingelsson E, Frayling TM, Weedon MN, Walker M, Quertermous T. Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene. J Clin Invest. 2016 Jan;126(1):403. doi: 10.1172/JCI85921. Epub 2016 Jan 4. PubMed PMID: 26727231;.

2.         Xie W, Wood AR, Lyssenko V, Weedon MN, Knowles JW, Alkayyali S, Assimes TL, Quertermous T, Abbasi F, et [14 authors].  Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes. Diabetes 2013 Jun; 61(6):2141-50.

3.         Kuo JZ, Sheu WH, Assimes TL, [9 authors], Knowles JW, [8 authors], Quertermous T, Rotter JI, Chen YD. Trans-ethnic fine mapping identifies a novel independent locus at the 3' end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population.  Diabetologia. 2013 Dec;56(12):2619-28.

4.         Dimas AS, Lagou V, Barker A, Knowles JW, [10 authors], Abbasi FA, Assimes TL, [28 authors], Quertemous T, [15 authors], Ingelsson E, McCarthy MI, Prokopenko I; on behalf of the MAGIC investigators. Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity.  Diabetes 2014 63(6):2158-71

5.         Kraja AT, Vaidya D, Pankow JS, Goodarzi MO, Assimes TL, Kullo IJ, +[32 authors], Borecki IB. A bivariate genome-wide approach to metabolic syndrome: STAMPEED Consortium. Diabetes 2011 Apr; 60 (4):1329