Hyongsok (Tom) Soh, PhD, Professor, Departments Electrical Engineering and Radiology, Stanford University Schools of Engineering and Medicine
Research Description: Dr. Soh is a Professor of Electrical Engineering and Radiology, and his laboratory’s work lies at the interface of Engineering and Medicine. Soh’s group is known for developing advanced biosensors that can achieve rapid, sensitive, specific, and multiplexed molecular measurements, especially at the point of care. His lab has extensive expertise in developing electrochemical biosensors, which are compatible with microfluidics and integrated circuits. His lab recently developed “real-time biosensors” that can continuously measure specific small molecules in live animals – with exquisite chemical specificity and sub-minute time resolution. This is one of the key technologies currently used in active collaborations with members of the Stanford DRC. This includes work with Stanford DRC groups led by Snyder, Kim and Maahs. Importantly, his lab is one of the leading research groups for generating aptamers (synthetic affinity reagents). His group was the first to utilize high-throughput sequencing (HTS) for aptamer discovery, which is now widely used. Most recently, his group invented the ‘particle display’ screening system, which transforms solution-phase aptamers into ‘aptamer particles’ that can be individually screened at high-throughput and reproducibly generate aptamers that can outperform best monoclonal antibodies in complex samples. This technique will be used to develop novel quantification methods for glucose, glucagon, insulin and other relevant biomolecules for diabetes and metabolic regulation.
Selected relevant publications (Stanford DRC members in BOLD):
1. Wang JP, Gong Q, Maheshwari N, Eisenstein M, Arcila ML, Kosik KS, and Soh HT “Particle display: A quantitative screening method for generating high-affinity aptamers” Angewandte Chemie International Ed. 53 (19) 4796–4801 (2014).
2. Hsieh K, Patterson AS, Ferguson BS, Plaxco KW, and Soh HT “Rapid, sensitive, and quantitative detection of pathogenic DNA at the point of care via microfluidic electrochemical quantitative loop-mediated isothermal amplification (MEQ-LAMP)”Angewandte Chemie International Ed. 51 (20) 4896-4900 (2012).
3. Ferguson BS, Hoggarth DA, Maliniak D, Ploense K, White RJ, Woodward N, Hsieh K, Bonham AJ, Eisenstein M, Kippin T, Plaxco KW, and Soh HT “Real-time, aptamer-based tracking of circulating therapeutic agents in living animals” Science Translational Medicine 5 (213) 213ra165 (2013).