ANDREAS Stahl

Andreas Stahl, PhD, Professor; Ruth Okey Chair, Nutritional Sciences & Toxicology, University of California, Berkeley

Research Description: The overarching goal of our laboratory is to advance human health by engineering solutions for obesity-related disorders such as Type-2 Diabetes Mellitus and Metabolic Dysfunction-Associated Steatotic Liver Disease. To this end, we are investigating molecular mechanisms governing lipid uptake, particularly for fatty acids and CoQ, mitochondrial function, hepatobiliary diseases, and adipocyte biology. We have been pioneering investigations into the role of biomechanical forces in brown adipose tissue (BAT) activation and are working on novel lipid nanoparticle and tissue engineering-based approaches to expand and activate BAT. Further, to facilitate the assessment of biological mechanisms and pharmacological intervention strategies in human systems, we are developing human induced pluripotent stem cell-based microphysiological systems, aka organ-on-a-chip devices, particularly for the functional interrogation of the fat-liver axis.