ANDREAS Stahl

Andreas Stahl, PhD, Professor; Ruth Okey Chair, Nutritional Sciences & Toxicology, University of California, Berkeley

Research Description: The overarching goal of our laboratory is to advance human health by engineering solutions for obesity-related disorders such as Type-2 Diabetes Mellitus and Metabolic Dysfunction-Associated Steatotic Liver Disease. To this end, we are investigating molecular mechanisms governing lipid uptake, particularly for fatty acids and CoQ, mitochondrial function, hepatobiliary diseases, and adipocyte biology. We have been pioneering investigations into the role of biomechanical forces in brown adipose tissue (BAT) activation and are working on novel lipid nanoparticle and tissue engineering-based approaches to expand and activate BAT. Further, to facilitate the assessment of biological mechanisms and pharmacological intervention strategies in human systems, we are developing human induced pluripotent stem cell-based microphysiological systems, aka organ-on-a-chip devices, particularly for the functional interrogation of the fat-liver axis.

Selected relevant publications (SDRC members in BOLD):

  1. Coassolo L, B Danneskiold-Samsøe N, Nguyen Q, Wiggenhorn A, Zhao M, Wang DC, Toomer D, Lone J, Wei Y, Patel A, Liparulo I, Kavi D, Wat LW, Reghupaty SC, Kim JJ, Asemi T, Bielczyk-Maczynska E, Li VL, Moya-Garzon MD, Krentz NAJ, Stahl A, Chou DH, Luo L, Svensson KJ. Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide. Nature. 2025 May;641(8061):192-201; PMCID: PMC12043402.

  2. Bielczyk-Maczynska E, Zhao M, Zushin PH, Schnurr TM, Kim HJ, Li J, Nallagatla P, Sangwung P, Park CY, Cornn C, Stahl A, Svensson KJ, Knowles JW. G protein-coupled receptor 151 regulates glucose metabolism and hepatic gluconeogenesis. Nat Commun. 2022 Dec 1;13(1):7408; PMCID: PMC9715671.

  3. Zhang Y, Shen WJ, Qiu S, Yang P, Dempsey G, Zhao L, Zhou Q, Hao X, Dong D, Stahl A, Kraemer FB, Leung LL, Morser J. Chemerin regulates formation and function of brown adipose tissue: Ablation results in increased insulin resistance with high fat challenge and aging. FASEB J. 2021 Jul;35(7):e21687; PMCID: PMC8958903.