john yoon

John Yoon, MD PhD, Associate Professor, Endocrinology, Diabetes, and Metabolism, Internal Medicine, University of California, Davis

Research Description: Dr. Yoon’s research focus is how adipose tissue controls systemic energy metabolism through modulation of glucose and lipid homeostasis, thermogenesis, and adipokine secretion. A sustained positive energy balance results in obesity, an important risk factor for type 2 diabetes mellitus and cardiovascular disease. Certain human conditions such as cancer cachexia or cystic fibrosis are characterized by a negative energy balance from inadequate nutrition and/or excessive energy expenditure. Restoring abnormally regulated energy metabolism is a significant goal in these conditions.

Selected relevant publications (Stanford DRC members are in BOLD)

1. An SM, Cho SH, Yoon JC. Adipose tissue and metabolic health. Diabetes and Metabolism Journal. 2023; 47(5): 595-611.

2. Choi KM, Ko CY, An SM, Cho SH, Rowland DJ, Kim JH, Fasoli A, Chaudhari AJ, Bers DM, Yoon JC. Regulation of beige adipocyte thermogenesis by the cold-repressed ER protein NNAT. Molecular Metabolism 2023; 69: 101679. PMCID: PMC9932177

3. Choi KM, Kim JH, Kong X, Isik M, Zhang J, Lim HW, Yoon JC. Defective brown adipose tissue thermogenesis and impaired glucose metabolism in mice lacking Letmd1. Cell Reports 2021; 37:110104.