Michael Z. Lin

Michael Z. Lin, MD, PhD, Professor of Neurobiology and Bioengineering, Stanford University

Research Description: The goal of Dr. Lin’s research has been to develop widely applicable methods for imaging and controlling physiological processes in vivo. His lab has used use chemistry-guided molecular engineering to improve fluorescent proteins for deep-tissue imaging and as biosensor components. Current work includes adapting and expanding the applications of NanoLuc luciferase for noninvasive in vivo study of metabolic processes. This includes improvement of enzyme function, identification of optimal substrates for brain and body imaging, and the design of new reporters of transmitters and hormones based on NanoLuc. Other projects include the engineering of the ASAP family of genetically encoded fluorescent voltage indicators for real-time imaging of bioelectricity in excitable cells, and the development of generalizable methods for optical and chemical control of protein activity in vivo. The Lin lab is currently applying these technologies toward real-time imaging of signaling events along the brain-body axis.

Selected relevant publications (SDRC members in BOLD):

  1. Labanieh L, Majzner RG, Klysz D, Sotillo E, Fisher CJ, Vilches-Moure JG, Pacheco KZB, Malipatlolla M, Xu P, Hui JH, Murty T, Theruvath J, Mehta N, Yamada-Hunter SA, Weber EW, Heitzeneder S, Parker KR, Satpathy AT, Chang HY, Lin MZ, Cochran JR, Mackall CL. Enhanced safety and efficacy of protease-regulated CAR-T cell receptors. Cell. 2022 May 12;185(10):1745-1763.e22. doi: 10.1016/j.cell.2022.03.041. Epub 2022 Apr 27. PMID: 35483375; PMCID: PMC9467936.