New research reveals Desert hedgehog signaling (Dhh) from neuroendocrine cells drives epithelial-mesenchymal feedback (EMF) signaling, protecting tissues like airways and pancreatic islets from injury, with implications for therapeutic strategies in airway damage and diabetes.

Dr. Agnieszka Czechowicz and colleagues used antibody treatment in a phase 1 clinical trial to enable blood-forming stem cell transplantation, an outcome that could pave the way for new islet replacement strategies in diabetes.

In a detailed analysis of post-meal glucose responses, SDRC investigators Tracey McLaughlin and Michael Snyder reveal how individual responses to common carbohydrates—like potatoes, grapes, and rice—are shaped by insulin resistance, beta cell function and their molecular profiles. The findings suggest a path to personalized nutrition and diabetes prevention.

Anna Gloyn, SDRC Investigator was elected Fellow of the Academy of Medical Sciences (United Kingdom) 2025 for Outstanding Contributions to Medical Science. 4T study led by David Maahs was awarded the prestigious CRF Top 10 Award. See links below for more information.

SDRC investigator uncovers an unexpected and crucial role of glucose, the body's primary energy source, in orchestrating tissue maturation, highlighting its significance in diabetes and cancer.